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Zuranolone Market

The market for Zuranolone was estimated at $116 million in 2025; it is anticipated to increase to $252 million by 2030, with projections indicating growth to around $546 million by 2035.

Report ID:DS1802008
Author:Debadatta Patel - Senior Consultant
Published Date:
Datatree
Life Science
Pharmaceutical
Zuranolone
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Report Summary
Market Data
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Table of Contents

Global Zuranolone Market Outlook

Revenue, 2025

$116M

Forecast, 2035

$545M

CAGR, 2026 - 2035

16.7%

The Zuranolone industry revenue is expected to be around $116.5 million in 2026 and expected to showcase growth with 16.7% CAGR between 2026 and 2035. A position of dominance in the treatment of central nervous system disorders is being established by Zuranolone, as there is considerable unmet need in cases of postpartum depression and major depressive disorder. The treatment of postpartum depression and major depression accounts for 94.4% of revenues generated from CNS disorder treatments. Zuranolones 30 mg dose has been the main driver of sales so far this year, bringing in $53.45 million in revenue for the industry by 2025. This is a sign of the strong support among doctors for Zuranolones treatment approach. This method involves taking a low dose orally for a short period of time. The trend is being driven by factors including growing evidence of rapid symptom relief for patients with MDD and PPD, greater awareness of mental health issues, regulatory developments, and an insurance industry that is increasingly willing to cover treatments that cut hospitalisation rates and improve patients quality of life.

This orally administered neuroactive steroid and a GABA-A receptor positive allosteric modulator has been engineered to provide fast antidepressant effects following the intake of a standard short once daily treatment of 14 days. This therefore provides an alternative to traditional monoaminergic oral antidepressants. Zuranolone, also known as Zurzuvae, exhibits a number of notable qualities including the swift alleviation of depression, its administration taking place at home, and a mechanism of action that involves the modulation of GABA. As such, it appears to hold significant promise for the treatment of postpartum depression and major depression where rapid recovery is a priority. Clinical trials of Zuranolone are not only limited to the treatment of PPD and depression but are also being conducted in other central nervous system disorders. The trials focus on 3 main factors: optimal dosing, the drug being given in combination with other antidepressants, and giving patients who live in different countries access to the treatment. Growing demand for antidepressants is driven by the increasing trend of screening for postpartum depression and the growing recognition of the fact that some forms of depression do not only respond to standard treatment. Another driver is the change in clinical practice guidelines for medications that affect GABA. Furthermore, Zuranolone is being used in tele psychiatry and in the community health care sector which tends towards giving patients medication that is effective, works quickly and is taken orally for a limited period.

Zuranolone market outlook with forecast trends, drivers, opportunities, supply chain, and competition 2025-2035
Zuranolone Market Outlook

Market Key Insights

  • The Zuranolone market is projected to grow from $116.5 million in 2025 to $546 million in 2035. This represents a CAGR of 16.7%, reflecting rising demand across Major Depressive Disorder (MDD) Treatment, Postpartum Depression (PPD) Therapy, and Generalized Anxiety Disorder (GAD).

  • The market for neurological treatments is highly concentrated, dominated by three leading pharmaceutical companies. One of these companies is Sage Therapeutics, which currently enjoys the biggest market share.

  • The United States and Germany are leading markets in the global Zuranolone market and will grow at a compound annual rate of 16% to 23.4% from 2025 to 2030.

  • The fastest rates of expansion are predicted for emerging markets such as Brazil, India and South Africa, with a compound annual growth rate ranging from 12.5% to 17.4% .

  • The investment appeal of the Zuranolone market is set to be improved by the shift to personalized medicine amongst other factors. The proposed changes are envisioned to foster a beneficial cycle that in turn fuels growth and should bring in approximately $15 million by the years 2030 and 2026.

  • Over the period 2025 to 2035 the market for Zuranolone will increase by $429 million. This growth in the market will largely be due to the Homecare & Mental Health Centers Application segment.

  • Research in neuroscience coupled with growing mental health awareness will be a factor in a 368% increase in the market for Zuranolone between 2035 and 2025.

zuranolone market size with pie charts of major and emerging country share, CAGR, trends for 2025 and 2032
Zuranolone - Country Share Analysis

Opportunities in the Zuranolone

In the United States, there is also a growing concern about womens mental health plus limited availability of successful treatment for postpartum depression. Zuranolone, a fast acting antidepressant and a neurosteroid that is orally administered, can reduce readmission of patients and lead to improved health of mothers after delivery by short duration dosing. The highest demand is anticipated for 20 mg and 25 mg formulations. The 25 mg variant is predicted to experience an 18.5% Compound Annual Growth Rate . The 20 mg option will be valued at $25.04 million in 2025, then $48.84 million by 2030.

Growth Opportunities in North America and Asia-Pacific

A rapid acting orally administered antidepressant such as Zuranolone is likely to be especially useful in the immediate term for treating postnatal depression in North America. This is due to a strong infrastructure being in place for fast access to treatment. This infrastructure includes established screening procedures, payers that are ready to provide coverage, and high levels of public awareness about perinatal mental health. This patient population suffering from treatment resistant depression or major depressive disorder could benefit from a CNS active drug, since the marketplace for CNS therapeutics is mature and doctors are well versed in the mechanisms of both GABA receptor modulators and neurosteroid activity. Key opportunities include the marketing of Zuranolone as an initial treatment for short periods of time in women who are severely depressed after giving birth in hospitals and other medical centres that offer obstetric care and psychiatric treatment. Another key opportunity exists in the prescribing of Zuranolone in patients who have depression that does not only respond to other treatments. Pills and other intravenous treatments in the pipeline for depression drive competition. As such, treatments must differentiate by highlighting their rapid onset of action, capacity to promote recovery and ease of use through oral dosing compared to intravenous treatments. The region has a number of factors which drive growth in the field. These factors include a relatively straightforward process for regulatory approvals, the presence of active bodies which set clinical practice guidelines, a strong voice for mental health advocacy and a comprehensive infrastructure for gathering data from real world usage. These factors allow for the implementation of premium pricing, for the negotiation of outcomes based contracts and to expand the labels of treatments for depression.
Across the Asia Pacific, the major depressive disorder holds considerable potential for Zuranolone sales, due to high untreated patient numbers, an increasingly stressful urban environment and a reduction in the stigma of mental illness. Furthermore, there is a rising demand for the drug in Japan, South Korea and Australia to treat postnatal depression. The company plans to focus on multiple aspects in order to capitalise on the Zuranolone market. This involves premium branding in those developed countries within the region and it also involves tailoring the dosing regimen. Additionally, the firm will have to supply data regarding the cost of medication in those middle income countries to ensure that the medicine is included in formularies for depression. In this competitive market, where cheaper generic medicines and regional antidepressant brands dominate, the importance of positioning Zuranolone as a distinct GABA receptor modulator and neurosteroid that possesses rapid acting antidepressant properties cannot be overstated. This is particularly relevant as it has the potential to reduce hospital stays and shorten the time to achieve a response. Key drivers of this market in the region are increased insurance coverage, a growing government commitment to mental health, the construction of psychiatric facilities and growing links between local medical experts and the company. These factors will help to bring the product to market, gain price approval and increase the market size in the region over time for the treatment of depression.

Market Dynamics and Supply Chain

01

Driver: Increasing Demand for Rapid‑Onset Antidepressants Combined with Rising Awareness of Mental Health Disorders

The zuranolone market is also being strongly driven by the growing demand for rapid‑onset antidepressant therapies and the expanding awareness of mental health disorders globally. Traditional antidepressants often take several weeks to show clinical benefits, creating a critical need for treatments like zuranolone that can also deliver faster symptom relief in conditions such as Major Depressive Disorder and Postpartum Depression. This rapid effectiveness is also especially valued in acute care settings, telepsychiatry, and community health programs where quick patient stabilization is also essential. Concurrently, increased screening, destigmatization, and broader public health initiatives have also heightened recognition of depression and anxiety disorders, leading to higher diagnosis rates and more patients seeking effective treatment options. Government and nonprofit campaigns emphasize early intervention and holistic care, encouraging clinicians to explore newer pharmacological classes beyond traditional monoaminergic drugs. As mental health becomes a priority in both developed and emerging markets, zuranolone’s unique mechanism and responsiveness to unmet clinical needs are also expanding its adoption among psychiatrists and neurologists, fueling market growth and investment in further clinical research.
A key driver for the zuranolone market is also the advancement of GABA‑targeting therapeutics within neuropsychiatric treatment paradigms. Zuranolone functions as a GABA‑A receptor positive allosteric modulator, distinguishing it from conventional antidepressants that focus primarily on serotonin, norepinephrine, or dopamine pathways. This mechanism offers a novel biological approach to alleviating depressive and anxiety symptoms by modulating inhibitory neurotransmission, which can also produce rapid clinical effects after relatively short treatment courses. also advances in precision medicine and biomarker research also support tailored treatment plans that identify patients most likely to benefit from GABA‑modulating drugs. Additionally, integration with digital health platforms and telemedicine enhances monitoring and adjustment of zuranolone dosing in real time, improving therapeutic outcomes. These technological and scientific trends emphasize personalized care, making zuranolone more attractive to clinicians seeking effective, mechanistically distinct options for complex mood disorders.
02

Restraint: High Treatment Cost and Limited Insurance Reimbursement Restrict Patient Access

A significant restraint for the zuranolone market is the high cost of therapy and inconsistent insurance coverage, which limits patient access and uptake. Zuranolone’s novel mechanism and specialty positioning often result in premium pricing, making it less affordable for many patients without comprehensive reimbursement. For example, inconsistent payer support for newer central nervous system therapies may reduce prescriptions, slow market penetration, and constrain revenue growth, especially in cost‑sensitive regions.
03

Opportunity: Expansion of Zuranolone-based major depressive disorder therapy in outpatient psychiatric clinics across Europe and Growth of Zuranolone 25 mg and 30 mg CNS therapeutics in Asia-Pacific urban populations

Growing pressure on European psychiatric facilities due to the increasing incidence of major depressive disorder makes outpatient clinics good settings for the administration of Zuranolone. This neuroactive steroid functions rapidly through the mouth and acts on the brain. It can lead to a quicker recovery and less follow up visits in comparison to standard antidepressants and can allow patients to leave the hospital sooner. Partnerships between the pharmaceutical industry and healthcare providers, along with digital therapeutics, can help ensure compliance and keep track of treatment. By 2030, Europe's therapy market for major depressive disorder is expected to be driven by a product with a dosage strength of 30 milligrams which, as of 2025, was already earning $53.45 million globally. By 2026, this will have a growth rate of 16.46%.
Growing urban populations, increased healthcare spending and lower social stigma in the Asia Pacific region have raised demand for central nervous system treatments, which will benefit the product Zuranolone. Japan, Australia and South Korea are focusing their health services on fast acting, innovative kinds of antidepressant medication which decrease the effect of depression and the loss of productivity the condition causes. By 2030, the projected global sales of the 25mg and 30mg doses, which target working age urban populations, are forecast to exceed $200 million. The 25mg formulation is predicted to increase from $37.96 million in 2025 to $88.71 million by the same year. The Asia Pacific region is expected to be the most rapidly expanding market for this of treatment.
04

Challenge: Uncertain Long‑Term Efficacy Data and Hesitancy Among Clinicians Slows Adoption

Another key challenge is the limited long‑term clinical evidence supporting zuranolone’s sustained efficacy and safety beyond short treatment courses. Healthcare providers may hesitate to prescribe it widely without extensive post‑approval data, particularly in chronic conditions like major depression. This clinical uncertainty can dampen demand, as physicians often favor well‑established antidepressants, influencing prescribing behavior and limiting broader market expansion for zuranolone.

Supply Chain Landscape

1

Zuranolone API Manufacturing

Sage TherapeuticsShionogi & Co. LtdWuXi AppTec
2

Neuroactive Steroid Formulation

Sage TherapeuticsCatalent Pharma SolutionsThermo Fisher Scientific
3

Global Pharma Distribution

McKesson CorporationCardinal HealthAmerisourceBergen
4

Therapeutic End Use

Major depressive disorderpostpartum depressionGABA receptor modulator therapy
Zuranolone - Supply Chain

Use Cases of Zuranolone in Major Depressive Disorder (MDD) Treatment & Generalized Anxiety Disorder (GAD)

Major Depressive Disorder (MDD) Treatment : Zuranolone, an orally administered neuroactive steroid and GABA‑A receptor positive allosteric modulator, is emerging as an innovative treatment option for MDD due to its rapid onset of antidepressant effects after a short once‑daily course. Unlike traditional monoaminergic antidepressants that may take weeks to work, zuranolone’s mechanism involves modulation of inhibitory GABA pathways, offering quicker symptomatic relief. Prescribed by psychiatrists and neurologists in outpatient and telepsychiatry settings, zuranolone is particularly beneficial for patients seeking fast improvement in depressive symptoms. Major pharmaceutical companies, including Sage Therapeutics in collaboration with Biogen, are advancing zuranolone’s clinical development and commercialization, emphasizing its potential to transform MDD care with a novel oral therapy that enhances patient adherence and quality of life.
Postpartum Depression (PPD) Therapy : Zuranolone has gained significant attention in the treatment of Postpartum Depression due to its ability to provide rapid mood stabilization in new mothers. Administered as a short, standard once‑daily treatment course, zuranolone addresses the urgent need for effective PPD therapies that can be used safely in the postnatal period. Its oral formulation enables convenient at‑home administration, expanding access beyond traditional clinical environments. Sage Therapeutics initially led zuranolone’s development, with regulatory approvals supporting its use in PPD and ongoing efforts to raise global awareness. Healthcare providers increasingly prefer zuranolone for its swift improvement in depressive symptoms, which can be critical for maternal health and early infant bonding. This advantage sets zuranolone apart from slower‑acting antidepressants in the maternal mental health landscape.
Generalized Anxiety Disorder (GAD) : Research into zuranolone’s application in Generalized Anxiety Disorder reflects growing interest in expanding its role beyond depression. Zuranolone’s modulation of the GABA‑A receptor, a key inhibitory neurotransmitter pathway, holds promise for reducing anxiety symptoms by restoring neural balance. Clinical trials and studies are evaluating optimal dosing strategies and combination approaches with other anxiolytic treatments to enhance efficacy and tolerability. End‑users include adults with moderate to severe anxiety who require rapid symptom control, with potential for use in both outpatient and community health settings. Pharma companies like Sage Therapeutics and partner Biogen are driving GAD research, reinforcing zuranolone’s position in the broader central nervous system therapeutics market and highlighting its potential to address unmet needs in anxiety management.

Recent Developments

Recent developments for zuranolone highlight expanded clinical evidence and broader regulatory momentum supporting its use in major depressive disorder, postpartum depression, and emerging anxiety disorder indications. A key market trend is the emphasis on rapid‑onset antidepressant therapies and neuropsychiatric treatment innovation, driven by growing mental health awareness and demand for alternatives to traditional SSRIs. Integration with telepsychiatry, enhanced patient compliance, and support from clinical trial networks further strengthen zuranolone’s positioning in the evolving CNS therapeutic landscape.

August 2023 : The U.S. Food and Drug Administration approved ZURZUVAE™ as the first and only oral treatment for adults with postpartum depression, enabling commercial launch and clinical adoption in late 2023.
February 2023 : The U.S. FDA accepted the New Drug Application for zuranolone to treat major depressive disorder and postpartum depression and granted priority review, setting the stage for its later approval.
September 2024 : Sage Therapeutics and Biogen terminated their collaboration on a separate program, while maintaining joint efforts to commercialize ZURZUVAE®, reaffirming ongoing strategic focus on zuranolone’s PPD market.

Impact of Industry Transitions on the Zuranolone Market

As a core segment of the Pharmaceutical industry, the Zuranolone market develops in line with broader industry shifts. Over recent years, transitions such as Shift Towards Personalized Medicine and Increased Investment in Mental Health Research have redefined priorities across the Pharmaceutical sector, influencing how the Zuranolone market evolves in terms of demand, applications and competitive dynamics. These transitions highlight the structural changes shaping long-term growth opportunities.
01

Shift Towards Personalized Medicine

Personalised treatment approaches are being driven by the trend of Zuranolone moving towards targeted medical care. This has brought about a change from a market where products were central to one where data drives precision care. As a result, the markets attractiveness to investors has been increased. With the integration of biomarkers and advanced analytical tools along with data from real world studies, Zuranolone offers a novel treatment solution in psychiatry which is precise and for depression. This transition allows for more effective treatments, reduces unwanted side effects, and allocates healthcare resources in a more efficient way across all brain disorder therapies, in turn winning support from both insurers and doctors. Between 2026 and 2030, Zuranolone in advanced neuropsychiatric care is expected to benefit from a self sustaining growth cycle as biomarker driven treatments are scaled up. This will add $15 million in market value and strengthen the firms position in the long term.
02

Increased Investment in Mental Health Research

The zuranolone market is benefiting from a surge in investment in mental health research, reflecting the growing recognition of the burden of depression, postpartum depression, and anxiety disorders worldwide. Funding for clinical trials, neuropsychiatric drug development, and innovative therapeutic approaches has accelerated the exploration of novel GABA‑modulating compounds like zuranolone. This transition has also positively impacted associated industries, including clinical trial management, contract research organizations, and telepsychiatry platforms, which support remote patient monitoring and data collection. For instance, Sage Therapeutics’ collaboration with Biogen and expansion of clinical studies across multiple countries illustrates how increased investment drives rapid product development, regulatory approvals, and wider access to effective, short-course oral antidepressants. Overall, heightened funding and research activity are catalyzing faster innovation cycles, strengthening industry infrastructure, and enhancing treatment options in the mental health sector.