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Small Interfering Rna Therapeutics Market
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Small Interfering Rna Therapeutics Market

Author: Debadatta Patel - Senior Consultant, Report ID - DS1804094, Published - August 2025

Segmented in Therapeutic Type (Oncology, Cardiovascular, Infectious Diseases), Applications (Clinical Research, Drug Discovery & Development, Genetic Disorders, Others), Delivery Method, End-User and Regions - Global Industry Analysis, Size, Share, Trends, and Forecast 2024 – 2034

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Global Small Interfering Rna Therapeutics
Market Outlook

The market for Small Interfering Rna Therapeutics was estimated at $1.3 billion in 2024; it is anticipated to increase to $3.5 billion by 2030, with projections indicating growth to around $8.1 billion by 2035. This expansion represents a compound annual growth rate (CAGR) of 18.2% over the forecast period. The market for Small Interfering RNA Therapeutics has expanded substantially because of various key factors. The main factor behind this growth is the rising number of genetic disorders and chronic diseases worldwide which requires new therapeutic approaches. The medical field has experienced a revolution through RNA interference technology which includes Small Interfering RNA Therapeutics because these treatments provide precise and efficient and minimally invasive therapeutic solutions. The market growth benefits from both ongoing biotechnology progress and increasing research and development funding. The medical field continues to value Small Interfering RNA Therapeutics because these treatments can specifically target genes that contribute to disease progression.


Small Interfering RNA Therapeutics functions as a drug class which utilizes RNA interference mechanisms to block disease-causing gene expression. The therapeutic method shows specificity because it targets only the genes of interest which minimizes potential side effects. Small Interfering RNA Therapeutics serves multiple therapeutic purposes including cancer treatment and genetic disorder management and viral infection management.


Market Size Forecast & Key Insights

2019
$1.3B2024
2029
$6.9B2034

Absolute Growth Opportunity = $5.6B

The Small Interfering Rna Therapeutics market is projected to grow from $1.3 billion in 2024 to $6.9 billion in 2034. This represents a CAGR of 18.2%, reflecting rising demand across Oncology Therapeutics, Viral Infections Management and Genetic Disorders Treatment.

The Small Interfering Rna Therapeutics market is set to add $5.6 billion between 2024 and 2034, with manufacturer targeting Drug Discovery & Development & Genetic Disorders Applications projected to gain a larger market share.

With Advancements in rnai technology, and Increasing prevalence of chronic diseases, Small Interfering Rna Therapeutics market to expand 432% between 2024 and 2034.

Opportunities in the Small Interfering Rna Therapeutics Market

Expanding into Untapped Markets

The Small Interfering RNA Therapeutics industry presents significant growth potential in untapped markets. The healthcare infrastructure of Asia and Africa is expanding while genetic disorder awareness grows in these emerging economies. The unmet needs in these regions create an ideal opportunity for Small Interfering RNA Therapeutics to expand its market presence.

Technological Innovations Driving Growth and Strategic Collaborations for Accelerated Development

The fast progress of biotechnology has enabled scientists to create better Small Interfering RNA Therapeutics through improved efficiency and effectiveness. The market will experience significant growth because of recent innovations in RNA interference technology. The application of AI and ML in research and development will speed up the discovery of new therapeutic agents.

The Small Interfering RNA Therapeutics market will benefit from strategic collaborations between pharmaceutical companies, research institutions, and biotech firms. The development and commercialization of new therapeutics will be accelerated through these partnerships which will drive market growth. These collaborations will also facilitate knowledge exchange and resource sharing which will enhance the overall efficiency and effectiveness of the research and development process.

Growth Opportunities in North America and Asia-Pacific

Asia Pacific Outlook

The Asia-Pacific region stands as an emerging market for Small Interfering RNA Therapeutics. The market expansion in this region results from growing healthcare spending combined with rising patient understanding and better healthcare facilities. The growing number of cancer and diabetes cases in India and China drives the need for advanced treatments which in turn drives up the market demand for Small Interfering RNA Therapeutics. The Small Interfering RNA Therapeutics market benefits from growing partnerships between international and domestic companies which creates competitive market dynamics and new market possibilities.

North America Outlook

The Small Interfering RNA Therapeutics market in North America demonstrates a substantial growth pattern. The market growth stems from the strong presence of biotechnology and pharmaceutical industries together with major investments in genomics and proteomics research. The region contains multiple prominent companies that focus on RNA therapeutics which creates an active competitive environment. The rising occurrence of chronic diseases and genetic disorders drives up the need for Small Interfering RNA Therapeutics. The market receives support from government backing through positive policies and funding for research and development activities.

North America Outlook

The Small Interfering RNA Therapeutics market in North America demonstrates a substantial growth pattern. The market growth stems from the strong presence of biotechnology and pharmaceutical industries together with major investments in genomics and proteomics research. The region contains multiple prominent companies that focus on RNA therapeutics which creates an active competitive environment. The rising occurrence of chronic diseases and genetic disorders drives up the need for Small Interfering RNA Therapeutics. The market receives support from government backing through positive policies and funding for research and development activities.

Asia-Pacific Outlook

The Asia-Pacific region stands as an emerging market for Small Interfering RNA Therapeutics. The market expansion in this region results from growing healthcare spending combined with rising patient understanding and better healthcare facilities. The growing number of cancer and diabetes cases in India and China drives the need for advanced treatments which in turn drives up the market demand for Small Interfering RNA Therapeutics. The Small Interfering RNA Therapeutics market benefits from growing partnerships between international and domestic companies which creates competitive market dynamics and new market possibilities.

Growth Opportunities in North America and Asia-Pacific

Established and Emerging Market's Growth Trend 2025–2034

1

Major Markets : U.S., Germany, UK, Japan, China are expected to grow at 17.5% to 25.5% CAGR

2

Emerging Markets : Brazil, South Africa, Malaysia are expected to grow at 13.6% to 18.9% CAGR

Market Analysis Chart

The Small Interfering RNA Therapeutics market is experiencing significant growth, driven by several key factors. One of the primary drivers is the increasing prevalence of genetic disorders and the urgent need for effective treatments. These therapeutics, with their ability to silence specific genes, offer a promising solution to tackle such diseases. Moreover, advancements in biotechnology are paving the way for the development of more efficient and targeted Small Interfering RNA Therapeutics. The integration of nanotechnology, for instance, has improved the delivery of these therapeutics, enhancing their efficacy and reducing potential side effects. However, the market also faces certain restraints. The complex nature of RNA interference technology poses challenges in drug development.

Recent Developments and Technological Advancement

December 2024

Global biotech firm, Genzyme Therapeutics, launched its novel Small Interfering RNA Therapeutics for the treatment of Huntingtons disease, marking a significant milestone in neurodegenerative disorder treatment

October 2024

RNAi Therapeutics Inc. announced a strategic partnership with MedTech Solutions to advance the development and commercialization of Small Interfering RNA Therapeutics in oncology

July 2024

BioNex Solutions, a leading provider in the Small Interfering RNA Therapeutics market, secured FDA approval for its innovative siRNA-based drug for the treatment of rare genetic disorders.

Recent market developments have significantly impacted the landscape of Small Interfering RNA Therapeutics. The industry has seen a surge in research and development activities, primarily driven by the growing prevalence of genetic disorders and the need for effective therapeutic solutions. The advent of advanced technologies in the field of RNA interference has paved the way for the development of innovative siRNA therapeutics, thereby propelling the market growth.

Impact of Industry Transitions on the Small Interfering Rna Therapeutics Market

As a core segment of the Biotechnology industry, the Small Interfering Rna Therapeutics market develops in line with broader industry shifts. Over recent years, transitions such as Advancements in Drug Delivery Systems and Regulatory Approvals and Commercialization have redefined priorities across the Biotechnology sector, influencing how the Small Interfering Rna Therapeutics market evolves in terms of demand, applications and competitive dynamics. These transitions highlight the structural changes shaping long-term growth opportunities.

1

Advancements in Drug Delivery Systems:

The Small Interfering RNA Therapeutics industry has experienced major developments in drug delivery systems. The advancements in drug delivery systems have made it possible to deliver Small Interfering RNA Therapeutics efficiently and precisely which improves their therapeutic effects. The creation of lipid nanoparticles has transformed the delivery of Small Interfering RNA Therapeutics by protecting them from degradation and improving their availability in the body. The transition has led to better patient results and has driven forward the development of pharmaceutical and biotechnology industries.

2

Regulatory Approvals and Commercialization:

The Small Interfering RNA Therapeutics industry has experienced a major transition with regulatory approvals and commercialization of Small Interfering RNA Therapeutics. The FDA approval of Patisiran, the first-ever Small Interfering RNA Therapeutic, marked a significant milestone in the industry. This transition has not only validated the potential of Small Interfering RNA Therapeutics but has also opened up new opportunities for the pharmaceutical industry and has set a precedent for regulatory authorities worldwide.

Global Events Shaping Future Growth

The chart below highlights how external events including emerging market developments, regulatory changes, and technological disruptions, have added another layer of complexity to the Biotechnology industry. These events have disrupted supply networks, changed consumption behavior, and reshaped growth patterns. Together with structural industry transitions, they demonstrate how changes within the Biotechnology industry cascade into the Small Interfering Rna Therapeutics market, setting the stage for its future growth trajectory.

Market Dynamics and Supply Chain

Driver: Advancements in RNAi Technology, and Rising Investments in Biopharmaceutical Research

The field of Small Interfering RNA Therapeutics is also experiencing rapid growth due to advancements in RNAi technology. This technology, which involves the use of small interfering RNAs to silence specific genes, is also being increasingly adopted in the development of novel therapeutics. These advancements are also expected to drive the growth of siRNA therapeutics, particularly in the treatment of genetic disorders and cancers where gene silencing can also play a crucial role.
The Small Interfering RNA Therapeutics market is also also being driven by the rising investments in biopharmaceutical research. These investments are also facilitating the development of innovative siRNA therapeutics and helping to accelerate their clinical trials.
The Small Interfering RNA Therapeutics market faces significant growth due to the rising occurrence of chronic diseases including cancer and diabetes and cardiovascular diseases. The therapeutic approach of siRNA works by targeting specific genes that are also dysregulated in these diseases thus offering a promising treatment solution. The market for siRNA therapeutics will also expand because patients need effective treatments for their chronic diseases.

Restraint: Regulatory Hurdles

Small Interfering RNA Therapeutics encounter major regulatory obstacles during their development and commercialization process. Health authorities across the world including the U. S. Food and Drug Administration and the European Medicines Agency enforce strict regulations on these therapeutics. The complete approval process which includes preclinical and clinical trials extends for multiple years while demanding significant financial investment. The lengthy approval process hinders market expansion and restricts these therapeutics from reaching patients who need them.

Challenge: Delivery Challenges

The successful application of Small Interfering RNA Therapeutics largely depends on efficient delivery systems. However, the development of such systems is a complex process, fraught with challenges such as ensuring stability, avoiding immune response, and achieving targeted delivery. These challenges can impede the progress of research and development in this field, thereby restraining the market growth.

Supply Chain Landscape

Raw Material Suppliers

Sigma-Aldrich

Thermo Fisher Scientific

Production

Alnylam Pharmaceuticals

Dicerna Pharmaceuticals

Distribution & Logistics
FedEx / DHL
End Users
Hospitals / Research Institutes / Biopharmaceutical Companies
Raw Material Suppliers

Sigma-Aldrich

Thermo Fisher Scientific

Production

Alnylam Pharmaceuticals

Dicerna Pharmaceuticals

Distribution & Logistics

FedEx

DHL

End Users

Hospitals

Research Institutes

Biopharmaceutical Companies

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Leading Providers and Their Strategies

Application AreaIndustryLeading Providers / ConsumersProvider Strategies
Oncology
Pharmaceuticals
Alnylam Pharmaceuticals
Developing a robust pipeline of Small Interfering RNA Therapeutics for various cancer types
Genetic Disorders
Biotechnology
Dicerna Pharmaceuticals
Focusing on the development of RNAi-based therapies for diseases caused by genetic mutations
Viral Infections
Healthcare
Arrowhead Pharmaceuticals
Leveraging the power of Small Interfering RNA Therapeutics to target and silence specific genes responsible for viral infections
Chronic Diseases
Medical
Sirnaomics Inc.
Strategizing to expand the application of Small Interfering RNA Therapeutics in the treatment of chronic diseases like diabetes and cardiovascular diseases

Elevate your strategic vision with in-depth analysis of key applications, leading market players, and their strategies. The report analyzes industry leaders' views and statements on the Small Interfering Rna Therapeutics market's present and future growth.

Our research is created following strict editorial standards. See our Editorial Policy

Applications of Small Interfering Rna Therapeutics in Genetic Disorders Treatment, Viral Infections Management and Oncology Therapeutics

Genetic Disorders Treatment

Small Interfering RNA Therapeutics are also employed in the treatment of genetic disorders. They are predominantly used to silence disease-causing genes, providing a novel approach to managing conditions that were previously untreatable. Ionis Pharmaceuticals and Alnylam Pharmaceuticals are leading the market in this application, with their strengths lying in their proprietary technologies and successful clinical trials.

Viral Infections Management

Another significant application of Small Interfering RNA Therapeutics is in the management of viral infections. These therapeutics can target and silence viral genes, preventing the replication of the virus and controlling the infection. Arrowhead Pharmaceuticals and Quark Pharmaceuticals are key market players in this application, recognized for their innovative RNA interference technologies and strong market presence.

Oncology Therapeutics

Small Interfering RNA Therapeutics, particularly those targeting specific oncogenes, have been widely used in the field of Oncology. They offer a unique advantage in selectively silencing genes that contribute to tumor growth, thereby inhibiting the progression of cancer. Top players in this field include Alnylam Pharmaceuticals and Dicerna Pharmaceuticals, both of which have a strong market position due to their innovative therapeutics and robust clinical pipelines.

Small Interfering Rna Therapeutics vs.
Substitutes: Performance and Positioning Analysis

Small Interfering RNA Therapeutics offers a targeted approach to gene silencing, distinguishing it from alternatives like CRISPR and Antisense Oligonucleotides. Its market positioning is promising, with potential growth driven by advancements in personalized medicine. These Alternatives specially Antisense Oligonucleotides has experienced a rapid growth as detailed in our latest report.

Small Interfering Rna Therapeutics
    Highly specific gene targeting, potential for treating a wide range of diseases
    Risk of off-target effects, delivery challenges
    Effective in treating a wide range of diseases, Ability to target multiple genes simultaneously
    Risk of off-target effects, High development and production costs

Small Interfering Rna Therapeutics vs.
Substitutes: Performance and Positioning Analysis

Small Interfering Rna Therapeutics

  • Highly specific gene targeting, potential for treating a wide range of diseases
  • Risk of off-target effects, delivery challenges

Antisense Oligonucleotides / MicroRNA Therapeutics / Gene Editing Therapeutics

  • Effective in treating a wide range of diseases, Ability to target multiple genes simultaneously
  • Risk of off-target effects, High development and production costs

Small Interfering RNA Therapeutics offers a targeted approach to gene silencing, distinguishing it from alternatives like CRISPR and Antisense Oligonucleotides. Its market positioning is promising, with potential growth driven by advancements in personalized medicine. These Alternatives specially Antisense Oligonucleotides has experienced a rapid growth as detailed in our latest report.

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Research Methodology

This market research methodology defines the Small Interfering Rna Therapeutics market scope, gathers reliable data, and validates findings using integrated primary and secondary research. Our systematic framework ensures precise market sizing, growth trend analysis, and competitive benchmarking.


Secondary Research Approach


We begin secondary research by defining the targeted market at Country and Regional levels. As part of the Biotechnology ecosystem, we analyze Small Interfering Rna Therapeutics across Pharmaceutical Companies, Biotechnology Companies, and Research Institutes Applications. Our team gathers data systematically from country level ministerial sources, industry associations & federations, trade databases, company annual & quarterly reports and other credential sources, enabling us to map global and regional market size, pricing trends, regulatory standards, and technology advancements.


Key Sources Referenced:


We benchmark competitors such as Alnylam Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., and Dicerna Pharmaceuticals Inc. by reviewing company financial statements, and regulatory filings. Our secondary insights identify key market drivers and constraints, forming the analytical foundation for primary research.


Primary Research Methods


We conduct structured interviews and surveys with industry stakeholders, including Raw Material Suppliers, Production, and Distribution & Logistics. Our geographic coverage spans Americas (40%), Europe (30%), Asia-Pacific (25%) and Middle East & Africa (5%). Our online surveys generally achieve a response rate of above 65%, and telephone interviews yield 60%, resulting in above 92% confidence level with a ±7% margin of error.


Through targeted questionnaires and in-depth interviews, we capture purchase intent, adoption barriers, brand perception across Segment Type. We use interview guides to ensure consistency and anonymous survey options to mitigate response bias. These primary insights validate secondary findings and align market sizing with real-world conditions.


Market Engineering & Data Analysis Framework


Our data analysis framework integrates Top-Down, Bottom-Up, and Company Market Share approaches to estimate and project market size with precision.


Top-down & Bottom-Up Process


In Top-down approach, we disaggregate global Biotechnology revenues to estimate the Small Interfering Rna Therapeutics segment, using historical growth patterns to set baseline trends. Simultaneously, in Bottom-up approach, we aggregate Country-Level Demand Data to derive regional and global forecasts, which provide granular consumption insights. By reconciling both approaches, we ensure statistical precision and cross-validation accuracy.


We evaluate the supply chain, spanning Raw Material Suppliers (Sigma-Aldrich, Thermo Fisher Scientific), Production (Alnylam Pharmaceuticals, Dicerna Pharmaceuticals), and Distribution & Logistics. Our parallel substitute analysis examines Antisense Oligonucleotides, MicroRNA Therapeutics, and Gene Editing Therapeutics, highlighting diversification opportunities and competitive risks.


Company Market Share & Benchmarking


We benchmark leading companies such as Alnylam Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., and Dicerna Pharmaceuticals Inc., analyzing their capabilities in pricing, product features, technology adoption, and distribution reach. By assessing company-level revenues and product portfolios, we derive market share comparisons, clarifying competitive positioning and growth trajectories across the ecosystem.


Our integration of data triangulation, supply chain evaluation, and company benchmarking, supported by our proprietary Directional Superposition methodology enables us to deliver precise forecasts and actionable strategic insights into the Small Interfering Rna Therapeutics market.


Quality Assurance and Compliance


We cross-reference secondary data with primary inputs and external expert reviews to confirm consistency. Further, we use stratified sampling, anonymous surveys, third-party interviews, and time-based sampling to reduce bias and strengthen our results.


Our methodology is developed in alignment with ISO 20252 standards and ICC/ESOMAR guidelines for research ethics. The study methodology follows globally recognized frameworks such as ISO 20252 and ICC codes of practice.

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Small Interfering Rna Therapeutics Market Data: Size, Segmentation & Growth Forecast

Report AttributeDetails
Market Value in 2025USD 1.5 billion
Revenue Forecast in 2034USD 6.9 billion
Growth RateCAGR of 18.2% from 2025 to 2034
Base Year for Estimation2024
Industry Revenue 20241.3 billion
Growth OpportunityUSD 5.6 billion
Historical Data2019 - 2023
Growth Projection / Forecast Period2025 - 2034
Market Size UnitsMarket Revenue in USD billion and Industry Statistics
Market Size 20241.3 billion USD
Market Size 20272.1 billion USD
Market Size 20293.0 billion USD
Market Size 20303.5 billion USD
Market Size 20346.9 billion USD
Market Size 20358.1 billion USD
Report CoverageMarket revenue for past 5 years and forecast for future 10 years, Competitive Analysis & Company Market Share, Strategic Insights & trends
Segments CoveredTherapeutic Type, Applications, Delivery Method, End-User
Regional scopeNorth America, Europe, Asia Pacific, Latin America and Middle East & Africa
Country scopeU.S., Canada, Mexico, UK, Germany, France, Italy, Spain, China, India, Japan, South Korea, Brazil, Mexico, Argentina, Saudi Arabia, UAE and South Africa
Companies ProfiledAlnylam Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., Dicerna Pharmaceuticals Inc., Ionis Pharmaceuticals Inc., Quark Pharmaceuticals Inc., Silence Therapeutics Plc, Sirnaomics Inc., Benitec Biopharma Inc., Gradalis Inc., miRagen Therapeutics Inc., RXi Pharmaceuticals Corp. and Sylentis S.A.
CustomizationFree customization at segment, region or country scope and direct contact with report analyst team for 10 to 20 working hours for any additional niche requirement which is almost equivalent to 10% of report value

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Table of Contents

Industry Insights Report - Table Of Contents

Chapter 1

Executive Summary

Major Markets & Their Performance - Statistical Snapshots

Chapter 2

Research Methodology

2.1Axioms & Postulates
2.2Market Introduction & Research MethodologyEstimation & Forecast Parameters / Major Databases & Sources
Chapter 3

Market Dynamics

3.1Market OverviewDrivers / Restraints / Opportunities / M4 Factors
3.2Market Trends
3.2.1Introduction & Narratives
3.2.2Market Trends - Impact Analysis(Short, Medium & Long Term Impacts)
3.3Supply Chain Analysis
3.4Porter's Five ForcesSuppliers & Buyers' Bargaining Power, Threat of Substitution & New Market Entrants, Competitive Rivalry
Chapter 4

Small Interfering Rna Therapeutics Market Size, Opportunities & Strategic Insights, by Therapeutic Type

4.1Oncology
4.2Cardiovascular
4.3Infectious Diseases
Chapter 5

Small Interfering Rna Therapeutics Market Size, Opportunities & Strategic Insights, by Applications

5.1Clinical Research
5.2Drug Discovery & Development
5.3Genetic Disorders
5.4Others
Chapter 6

Small Interfering Rna Therapeutics Market Size, Opportunities & Strategic Insights, by Delivery Method

6.1Lipid Nanoparticle
6.2Electroporation
6.3Hydrodynamic Delivery
Chapter 7

Small Interfering Rna Therapeutics Market Size, Opportunities & Strategic Insights, by End-User

7.1Pharmaceutical Companies
7.2Biotechnology Companies
7.3Research Institutes
7.4Others
Chapter 8

Small Interfering Rna Therapeutics Market, by Region

8.1North America Small Interfering Rna Therapeutics Market Size, Opportunities, Key Trends & Strategic Insights
8.1.1U.S.
8.1.2Canada
8.2Europe Small Interfering Rna Therapeutics Market Size, Opportunities, Key Trends & Strategic Insights
8.2.1Germany
8.2.2France
8.2.3UK
8.2.4Italy
8.2.5The Netherlands
8.2.6Rest of EU
8.3Asia Pacific Small Interfering Rna Therapeutics Market Size, Opportunities, Key Trends & Strategic Insights
8.3.1China
8.3.2Japan
8.3.3South Korea
8.3.4India
8.3.5Australia
8.3.6Thailand
8.3.7Rest of APAC
8.4Middle East & Africa Small Interfering Rna Therapeutics Market Size, Opportunities, Key Trends & Strategic Insights
8.4.1Saudi Arabia
8.4.2United Arab Emirates
8.4.3South Africa
8.4.4Rest of MEA
8.5Latin America Small Interfering Rna Therapeutics Market Size, Opportunities, Key Trends & Strategic Insights
8.5.1Brazil
8.5.2Mexico
8.5.3Rest of LA
8.6CIS Small Interfering Rna Therapeutics Market Size, Opportunities, Key Trends & Strategic Insights
8.6.1Russia
8.6.2Rest of CIS
Chapter 9

Competitive Landscape

9.1Competitive Dashboard & Market Share Analysis
9.2Company Profiles (Overview, Financials, Developments, SWOT)
9.2.1Alnylam Pharmaceuticals Inc.
9.2.2Arrowhead Pharmaceuticals Inc.
9.2.3Dicerna Pharmaceuticals Inc.
9.2.4Ionis Pharmaceuticals Inc.
9.2.5Quark Pharmaceuticals Inc.
9.2.6Silence Therapeutics Plc
9.2.7Sirnaomics Inc.
9.2.8Benitec Biopharma Inc.
9.2.9Gradalis Inc.
9.2.10miRagen Therapeutics Inc.
9.2.11RXi Pharmaceuticals Corp.
9.2.12Sylentis S.A.