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Pretomanid Market
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Pretomanid Market

Author: Debadatta Patel - Senior Consultant, Report ID - DS1802142, Published - April 2025

Segmented in Patient Age Group (Pediatric, Adult, Geriatric), Therapeutic Application (TB Treatment, Nix-TB Regimen, BPaL Regimen, Others), Distribution Channel and Regions - Global Industry Analysis, Size, Share, Trends, and Forecast 2024 – 2034

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Global Pretomanid Market Outlook

The market, for Pretomanid was estimated at $459.1 million in 2024; and it is anticipated to increase to $712.5 million by 2030 with projections indicating a growth to around $1.0 billion by 2035. This expansion represents a compound annual growth rate (CAGR) of 7.6% over the forecast period. The emergent and dynamic nature of the Pretomanid market underscores its significance in today's healthcare landscape. Its sustained growth trajectory mirrors the escalating demand for more effective tuberculosis treatments, spurred by an expanding patient pool and the continued prevalence of multi-drug-resistant strains. Increased influx in research and development funding, along with the successful efforts to raise global health awareness, have resulted in a trend of advancing innovations in this field, which further amplifies Pretomanids relevance in modern medicine


As an FDA-approved novel medication, Pretomanid, is part of the bedaquiline, pretomanid and linezolid (BPaL) regimen, a formidable treatment for extensively drug-resistant tuberculosis (XDR-TB) and treatment-intolerant or non-responsive multidrug-resistant tuberculosis (MDR-TB). These cutting-edge applications amplified by evolving trends in healthcare like personalized care, rapid diagnostics, and the thrust on management of drug-resistant infections, have helped catapult Pretomanid into the forefront of tuberculosis treatment.


Market Size Forecast & Key Insights

2019
$459M2024
2029
$955M2034

Absolute Growth Opportunity = $496M

The Pretomanid market is projected to grow from $459.1 million in 2024 to $955 million in 2034. This represents a CAGR of 7.6%, reflecting rising demand across Tuberculosis Treatment, Antimicrobial Resistance Counteraction and Preclinical Cancer Research.

The Pretomanid market is set to add $496 million between 2024 and 2034, with manufacturer targeting Nix-TB Regimen & BPaL Regimen Therapeutic Application projected to gain a larger market share.

With Rise in multidrug-resistant tuberculosis , and Increased access to tuberculosis diagnostics, Pretomanid market to expand 108% between 2024 and 2034.

Opportunities in the Pretomanid Market

Strategic Partnerships for Advanced Research Collaborations

Forming strategic partnerships with research institutions and other corporations in the pharmaceutical industry could present another avenue for growth. These collaborations can help in clinical trials, research and development, and in gaining regulatory approvals faster.

Expanding into Untapped Markets and Technological Advancements and their Application to Drug Development

Pretomanid, as part of innovative antituberculosis drug regimens, has the potential to tap into new markets globally. Less developed countries with high TB burdens, particularly in Africa and Asia, are in desperate need of effective treatments. Expanding into these markets could have significant implications for the reduction of TB and present an untapped potential for the growth of Pretomanid in terms of both applications and sales.

The fast-paced innovations in drug development technologies could also serve as a significant for Pretomanid. Emerging techniques, such as drug delivery systems and precision medicine, can help improve the drugs efficacy, safety, and patient compliance. This could enable Pretomanid to be used in a broader spectrum of patient populations and therefore expand its current market reach.

Growth Opportunities in North America and Europe

Europe Outlook

Europe shows substantial potential for Pretomanid adoption due to its advanced healthcare facilities, research institutions, and an aging population susceptible to tuberculosis. Despite a highly competitive environment characterized by the presence of multiple pharmaceutical companies and a robust regulatory framework, Pretomanid has cemented its position in the European market. The ever-growing need for effective remedies for multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis predicates the regions persistent demand for Pretomanid. Policymakers, industry practitioners, and medical professionals daily interplay and discourse drive the increased availability and prominence of Pretomanid in the European region.

North America Outlook

As a crucial pharmaceutical enclave, North America houses numerous pharmaceutical giants invested in the production and distribution of Pretomanid, thereby making it a crucial player in this industry. This regions steady growth can be attributed to its advanced medical infrastructure and the high prevalence of tuberculosis, necessitating the increased use of Pretomanid. The region continues to witness significant investment in research and development activities, fostering innovation, and emphasizing the role of Pretomanid as a vital player in the tuberculosis treatment market. Stiff competition among market players in the region, including pharmacies, hospitals, and research institutions, further escalates the demand for Pretomanid, powering market dynamics.

North America Outlook

As a crucial pharmaceutical enclave, North America houses numerous pharmaceutical giants invested in the production and distribution of Pretomanid, thereby making it a crucial player in this industry. This regions steady growth can be attributed to its advanced medical infrastructure and the high prevalence of tuberculosis, necessitating the increased use of Pretomanid. The region continues to witness significant investment in research and development activities, fostering innovation, and emphasizing the role of Pretomanid as a vital player in the tuberculosis treatment market. Stiff competition among market players in the region, including pharmacies, hospitals, and research institutions, further escalates the demand for Pretomanid, powering market dynamics.

Europe Outlook

Europe shows substantial potential for Pretomanid adoption due to its advanced healthcare facilities, research institutions, and an aging population susceptible to tuberculosis. Despite a highly competitive environment characterized by the presence of multiple pharmaceutical companies and a robust regulatory framework, Pretomanid has cemented its position in the European market. The ever-growing need for effective remedies for multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis predicates the regions persistent demand for Pretomanid. Policymakers, industry practitioners, and medical professionals daily interplay and discourse drive the increased availability and prominence of Pretomanid in the European region.

Growth Opportunities in North America and Europe

Established and Emerging Market's Growth Trend 2025–2034

1

Major Markets : United States, United Kingdom, Germany, Japan, Canada are expected to grow at 4.9% to 7.3% CAGR

2

Emerging Markets : India, South Africa, Brazil are expected to grow at 8.7% to 10.5% CAGR

Market Analysis Chart

Pretomanid, a vital part of the TB drug market, holds a substantial influence in the global healthcare industry. Market drivers for Pretomanid primarily revolve around the escalating rates of tuberculosis, particularly drug-resistant strains. The high efficacy of Pretomanid, compounded by its role in breakthrough treatments, underscore its upward trajectory in pharmaceuticals. Yet, despite its potency against TB, Pretomanid faces significant market constraints.

Recent Developments and Technological Advancement

December 2024

Due to the increasing demand for Pretomanid, leading pharmaceutical company Roche announced a scaling up of their production facilities to improve the global supply chain for the drug.

October 2024

FDA approves the application of Pretomanid in combination with bedaquiline and linezolid, an advanced regimen for highly drug-resistant forms of tuberculosis, establishing Pretomanid as a major contender in drug-resistant TB treatment.

August 2024

Johnson & Johnson, in collaboration with Global Alliance for TB Drug Development, initiates an advanced clinical trial for a new drug regimen involving Pretomanid, aiming to enhance TB treatment outcomes and reduce the treatment period.

Pretomanid, an innovative pharmaceutical product, made significant strides within the healthcare industry. This distinctive medicine, used in treating tuberculosis, has undeniably shaped market trends. In response to an increasing demand for effective tuberculosis treatment, Pretomanids popularity has surged across global markets.

Impact of Industry Transitions on the Pretomanid Market

As a core segment of the Pharmaceutical industry, the Pretomanid market develops in line with broader industry shifts. Over recent years, transitions such as The Journey Towards Drug Resistance and Acceleration of Drug Approvals have redefined priorities across the Pharmaceutical sector, influencing how the Pretomanid market evolves in terms of demand, applications and competitive dynamics. These transitions highlight the structural changes shaping long-term growth opportunities.

1

The Journey Towards Drug Resistance:

In recent years, the medical world has observed a significant industry transition towards the fight against drugresistant diseases. Pretomanid, as a novel antituberculosis agent, stands at the forefront of this transition. The staggering growth of drugresistant TB cases worldwide highlights the urgent need for neweffective drugs, and Pretomanid answers this call. The introduction of Pretomanid, especially in combination therapies, has impacted not only the pharmaceutical sphere but also healthcare providers and patients, spurring hope and setting a precedence for future antiTB medication development.

2

Acceleration of Drug Approvals:

In tandem with the above, regulatory bodies like the FDA are accelerating the approval of lifesaving drugs like Pretomanid. Traditionally, the process of new drug approval is lengthy, intense and costly. However, recognizing the urgent need for effective medications to control increasing TB cases, faster approval processes are becoming the new norm. This regulatory transition directly impacts drug manufacturers, urging them to expedite their medical innovations.

Global Events Shaping Future Growth

The chart below highlights how external events including emerging market developments, regulatory changes, and technological disruptions, have added another layer of complexity to the Pharmaceutical industry. These events have disrupted supply networks, changed consumption behavior, and reshaped growth patterns. Together with structural industry transitions, they demonstrate how changes within the Pharmaceutical industry cascade into the Pretomanid market, setting the stage for its future growth trajectory.

Market Dynamics and Supply Chain

Driver: Rise in Multidrug-Resistant Tuberculosis , and Growing Demand in Emerging Economies

The surge in multidrug-resistant tuberculosis cases worldwide presents a significant for the growth of the Pretomanid market. This can also primarily be attributed to Pretomanids effectiveness as the second-line treatment for drug-resistant forms of TB, including multidrug-resistant TB , and extensively drug-resistant TB .
Population growth, along with an increase in the incidence of MDR-TB and XDR-TB in low and middle-income countries, has also fueled the demand for Pretomanid. These economies often struggle to provide adequate treatment for TB due to limited resources, enhancing the need for effective solutions like Pretomanid in combating the disease.
also Advances in diagnostics and increased accessibility to testing services have also led to more people being diagnosed with TB, including its drug-resistant strains. This surge in diagnoses also drives the demand for Pretomanid, which is also utilized in the treatment of these severe forms of TB.

Restraint: Limited Awareness

One key impeding Pretomanid market growth is the limited awareness of this antibiotics benefits in treating specific forms of tuberculosis. Especially in developing countries, there are significant knowledge gaps concerning this medical breakthrough. The lack of understanding and awareness about Pretomanids efficacy often leads to underutilization, thereby affecting market demand negatively and dampening growth potential. Enhanced stakeholder education and public awareness campaigns could play a pivotal role in overcoming this .

Challenge: Regulatory barriers

Another major is the stringent regulatory barriers that Pretomanid, like many other pharmaceutical products, faces. Regulatory approvals are essential for the market availability of any drug, including Pretomanid. Unfortunately, these processes can be complex, time-consuming, and differ significantly across geographic regions, hence slowing the drugs commercialization process. These regulatory challenges directly impact market dynamics by restricting the availability of Pretomanid, thus limiting potential market expansion.

Supply Chain Landscape

Raw Material Suppliers

Johnson Matthey

BASF

Intermediate Product Producers

Mylan Laboratories

Lupin Pharmaceuticals

API Manufacturers
Pfizer / Sanofi
End-Use
Hospital Pharmacies / Retail Pharmacies
Raw Material Suppliers

Johnson Matthey

BASF

Intermediate Product Producers

Mylan Laboratories

Lupin Pharmaceuticals

API Manufacturers

Pfizer

Sanofi

End-Use

Hospital Pharmacies

Retail Pharmacies

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Elevate your strategic vision with in-depth analysis of key applications, leading market players, and their strategies. The report analyzes industry leaders' views and statements on the Pretomanid market's present and future growth.

Our research is created following strict editorial standards. See our Editorial Policy

Applications of Pretomanid in Preclinical Cancer Research and Antimicrobial Resistance Counteraction and Tuberculosis Treatment

Preclinical Cancer Research and Antimicrobial Resistance Counteraction

Another application of Pretomanid resides in preclinical investigation aimed at cancer therapeutics. The nitroimidazole class of antibiotics, which includes Pretomanid, showcases potential anti-cancer properties by causing cell death in hypoxic tumour tissues that are typically resistant to conventional treatments. The American biopharmaceutical company Global Cancer Technology is at the forefront of these research applications, demonstrating the potential of Pretomanid in this novel role.



Pretomanid also holds great promise in dealing with Antimicrobial Resistance due to its unique mechanism of action. It works by disrupting the bacterial cells energy creation process, leading to cell death.

Tuberculosis Treatment

In the global healthcare industry, the primary use of Pretomanid is found in the innovative regimes designed for combating drug-resistant Tuberculosis. Pretomanid is an integral part of the BPaL regimen , which is extensively employed in treating extensively drug-resistant tuberculosis and multi-drug-resistant tuberculosis . The unique advantage of this regimen is its high cure rate, often exceeding 90% cases, which signals a transformative leap in TB treatment. The most notable global player leveraging this technology is The Global Alliance for TB Drug Development, championing in the development and spread of Pretomanid for TB treatment.

Pretomanid vs. Substitutes:
Performance and Positioning Analysis

Pretomanid outperforms its counterparts by exhibiting superior efficacy for treating drug-resistant tuberculosis, coupled with reduced treatment duration. Its unique market positioning lies in tackling multi-drug resistant conditions, unlocking massive potential for growth. These Alternatives specially Bedaquiline has experienced a rapid growth as detailed in our latest report.

Pretomanid
    Effective treatment for drug-resistant tuberculosis, significant reduction in treatment duration
    Expensive, potential side effects including hepatic disorders, and QT prolongation
    Effective treatment for multi-drug resistant tuberculosis, lower rate of adverse effects
    Limited availability, expensive treatment costs

Pretomanid vs. Substitutes:
Performance and Positioning Analysis

Pretomanid

  • Effective treatment for drug-resistant tuberculosis, significant reduction in treatment duration
  • Expensive, potential side effects including hepatic disorders, and QT prolongation

Bedaquiline / Delamanid / Linezolid

  • Effective treatment for multi-drug resistant tuberculosis, lower rate of adverse effects
  • Limited availability, expensive treatment costs

Pretomanid outperforms its counterparts by exhibiting superior efficacy for treating drug-resistant tuberculosis, coupled with reduced treatment duration. Its unique market positioning lies in tackling multi-drug resistant conditions, unlocking massive potential for growth. These Alternatives specially Bedaquiline has experienced a rapid growth as detailed in our latest report.

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Research Methodology

This market research methodology defines the Pretomanid market scope, gathers reliable data, and validates findings using integrated primary and secondary research. Our systematic framework ensures precise market sizing, growth trend analysis, and competitive benchmarking.


Secondary Research Approach


We begin secondary research by defining the targeted market at Country and Regional levels. As part of the Pharmaceutical ecosystem, we analyze Pretomanid across TB Treatment, Nix-TB Regimen, and BPaL Regimen Applications. Our team gathers data systematically from country level ministerial sources, industry associations & federations, trade databases, company annual & quarterly reports and other credential sources, enabling us to map global and regional market size, pricing trends, regulatory standards, and technology advancements.


Key Sources Referenced:


We benchmark competitors such as Mylan NV, TB Alliance, and Sequire Life Sciences by reviewing company financial statements, and regulatory filings. Our secondary insights identify key market drivers and constraints, forming the analytical foundation for primary research.


Primary Research Methods


We conduct structured interviews and surveys with industry stakeholders, including Raw Material Suppliers, Intermediate Product Producers, and API Manufacturers. Our geographic coverage spans Americas (40%), Europe (30%), Asia-Pacific (25%) and Middle East & Africa (5%). Our online surveys generally achieve a response rate of above 65%, and telephone interviews yield 60%, resulting in above 92% confidence level with a ±7% margin of error.


Through targeted questionnaires and in-depth interviews, we capture purchase intent, adoption barriers, brand perception across Segment Type. We use interview guides to ensure consistency and anonymous survey options to mitigate response bias. These primary insights validate secondary findings and align market sizing with real-world conditions.


Market Engineering & Data Analysis Framework


Our data analysis framework integrates Top-Down, Bottom-Up, and Company Market Share approaches to estimate and project market size with precision.


Top-down & Bottom-Up Process


In Top-down approach, we disaggregate global Pharmaceutical revenues to estimate the Pretomanid segment, using historical growth patterns to set baseline trends. Simultaneously, in Bottom-up approach, we aggregate Country-Level Demand Data to derive regional and global forecasts, which provide granular consumption insights. By reconciling both approaches, we ensure statistical precision and cross-validation accuracy.


We evaluate the supply chain, spanning Raw Material Suppliers (Johnson Matthey, BASF), Intermediate Product Producers (Mylan Laboratories, Lupin Pharmaceuticals), and API Manufacturers. Our parallel substitute analysis examines Bedaquiline, Delamanid, and Linezolid, highlighting diversification opportunities and competitive risks.


Company Market Share & Benchmarking


We benchmark leading companies such as Mylan NV, TB Alliance, and Sequire Life Sciences, analyzing their capabilities in pricing, product features, technology adoption, and distribution reach. By assessing company-level revenues and product portfolios, we derive market share comparisons, clarifying competitive positioning and growth trajectories across the ecosystem.


Our integration of data triangulation, supply chain evaluation, and company benchmarking, supported by our proprietary Directional Superposition methodology enables us to deliver precise forecasts and actionable strategic insights into the Pretomanid market.


Quality Assurance and Compliance


We cross-reference secondary data with primary inputs and external expert reviews to confirm consistency. Further, we use stratified sampling, anonymous surveys, third-party interviews, and time-based sampling to reduce bias and strengthen our results.


Our methodology is developed in alignment with ISO 20252 standards and ICC/ESOMAR guidelines for research ethics. The study methodology follows globally recognized frameworks such as ISO 20252 and ICC codes of practice.

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Pretomanid Market Data: Size, Segmentation & Growth Forecast

Report AttributeDetails
Market Value in 2025USD 494 million
Revenue Forecast in 2034USD 955 million
Growth RateCAGR of 7.6% from 2025 to 2034
Base Year for Estimation2024
Industry Revenue 2024459 million
Growth OpportunityUSD 496 million
Historical Data2019 - 2023
Growth Projection / Forecast Period2025 - 2034
Market Size UnitsMarket Revenue in USD million and Industry Statistics
Market Size 2024459 million USD
Market Size 2027571 million USD
Market Size 2029662 million USD
Market Size 2030712 million USD
Market Size 2034955 million USD
Market Size 20351.03 billion USD
Report CoverageMarket revenue for past 5 years and forecast for future 10 years, Competitive Analysis & Company Market Share, Strategic Insights & trends
Segments CoveredPatient Age Group, Therapeutic Application, Distribution Channel
Regional scopeNorth America, Europe, Asia Pacific, Latin America and Middle East & Africa
Country scopeU.S., Canada, Mexico, UK, Germany, France, Italy, Spain, China, India, Japan, South Korea, Brazil, Mexico, Argentina, Saudi Arabia, UAE and South Africa
Companies ProfiledMylan NV, TB Alliance, Sequire Life Sciences, Johnson & Johnson, AstraZeneca, GlaxoSmithKline, Novartis AG, Pfizer Inc., Sanofi, Lupin Limited, Cipla Limited and Eli Lilly and Company
CustomizationFree customization at segment, region or country scope and direct contact with report analyst team for 10 to 20 working hours for any additional niche requirement which is almost equivalent to 10% of report value

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Table of Contents

Industry Insights Report - Table Of Contents

Chapter 1

Executive Summary

Major Markets & Their Performance - Statistical Snapshots

Chapter 2

Research Methodology

2.1Axioms & Postulates
2.2Market Introduction & Research MethodologyEstimation & Forecast Parameters / Major Databases & Sources
Chapter 3

Market Dynamics

3.1Market OverviewDrivers / Restraints / Opportunities / M4 Factors
3.2Market Trends
3.2.1Introduction & Narratives
3.2.2Market Trends - Impact Analysis(Short, Medium & Long Term Impacts)
3.3Supply Chain Analysis
3.4Porter's Five ForcesSuppliers & Buyers' Bargaining Power, Threat of Substitution & New Market Entrants, Competitive Rivalry
Chapter 4

Pretomanid Market Size, Opportunities & Strategic Insights, by Patient Age Group

4.1Pediatric
4.2Adult
4.3Geriatric
Chapter 5

Pretomanid Market Size, Opportunities & Strategic Insights, by Therapeutic Application

5.1TB Treatment
5.2Nix-TB Regimen
5.3BPaL Regimen
5.4Others
Chapter 6

Pretomanid Market Size, Opportunities & Strategic Insights, by Distribution Channel

6.1Hospital Pharmacies
6.2Retail Pharmacies
6.3Online Pharmacies
Chapter 7

Pretomanid Market, by Region

7.1North America Pretomanid Market Size, Opportunities, Key Trends & Strategic Insights
7.1.1U.S.
7.1.2Canada
7.2Europe Pretomanid Market Size, Opportunities, Key Trends & Strategic Insights
7.2.1Germany
7.2.2France
7.2.3UK
7.2.4Italy
7.2.5The Netherlands
7.2.6Rest of EU
7.3Asia Pacific Pretomanid Market Size, Opportunities, Key Trends & Strategic Insights
7.3.1China
7.3.2Japan
7.3.3South Korea
7.3.4India
7.3.5Australia
7.3.6Thailand
7.3.7Rest of APAC
7.4Middle East & Africa Pretomanid Market Size, Opportunities, Key Trends & Strategic Insights
7.4.1Saudi Arabia
7.4.2United Arab Emirates
7.4.3South Africa
7.4.4Rest of MEA
7.5Latin America Pretomanid Market Size, Opportunities, Key Trends & Strategic Insights
7.5.1Brazil
7.5.2Mexico
7.5.3Rest of LA
7.6CIS Pretomanid Market Size, Opportunities, Key Trends & Strategic Insights
7.6.1Russia
7.6.2Rest of CIS
Chapter 8

Competitive Landscape

8.1Competitive Dashboard & Market Share Analysis
8.2Company Profiles (Overview, Financials, Developments, SWOT)
8.2.1Mylan NV
8.2.2TB Alliance
8.2.3Sequire Life Sciences
8.2.4Johnson & Johnson
8.2.5AstraZeneca
8.2.6GlaxoSmithKline
8.2.7Novartis AG
8.2.8Pfizer Inc.
8.2.9Sanofi
8.2.10Lupin Limited
8.2.11Cipla Limited
8.2.12Eli Lilly and Company