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Glycerol Phenylbutyrate Liquid Market

Glycerol Phenylbutyrate Liquid Market

The market for Glycerol Phenylbutyrate Liquid was estimated at $137 million in 2024; it is anticipated to increase to $474 million by 2030, with projections indicating growth to around $1.34 billion by 2035.

Report ID:DS1802094
Author:Debadatta Patel - Senior Consultant
Published Date:March 2025
Datatree
Life Science
Pharmaceutical
Glycerol Phenylbutyrate Liquid
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Report Summary
Table of Contents
Methodology
Market Data

Global Glycerol Phenylbutyrate Liquid Market Outlook

Revenue, 2024

$137M

Forecast, 2034

$1.09B

CAGR, 2024 - 2034

23.0%
The Glycerol Phenylbutyrate Liquid industry revenue is expected to be around $168.5 million in 2025 and expected to showcase growth with 23.0% CAGR between 2025 and 2034. This burgeoning growth can largely be attributed to the increasing global focus on managing the volume of ammonia in the blood, particularly for individuals with urea cycle disorders. Therefore, the significance of glycerol phenylbutyrate liquid is rapidly elevating in the healthcare industry, which remains the products primary market. Key driving factors, such as advancements in healthcare technology, stakeholder investments, and the rising incidence of rare metabolic diseases, are all contributing to its ongoing relevance in pharmaceutical therapies.

Glycerol phenylbutyrate liquid, Therapeutic-grade GPB, is a key player in this dynamic healthcare landscape. The compound serves as a vital nitrogen-binding agent, assisting in the removal of excess nitrogen caused by metabolic processes. This makes GPB instrumental in treating urea cycle disorders, thereby preventing an array of potential complications including nervous system damage and organ failure.

Glycerol Phenylbutyrate Liquid market outlook with forecast trends, drivers, opportunities, supply chain, and competition 2024-2034

Market Key Insights

  • The Glycerol Phenylbutyrate Liquid market is projected to grow from $137.0 million in 2024 to $1.09 billion in 2034. This represents a CAGR of 23%, reflecting rising demand across Urea Cycle Disorders Treatment, Research and Development and Hepatic Encephalopathy Management.
  • Horizon Therapeutics, Vertice Pharma, Cipher Pharmaceuticals are among the leading players in this market, shaping its competitive landscape.
  • U.S. and Germany are the top markets within the Glycerol Phenylbutyrate Liquid market and are expected to observe the growth CAGR of 22.1% to 32.2% between 2024 and 2030.
  • Emerging markets including Brazil, South Africa and Malaysia are expected to observe highest growth with CAGR ranging between 17.3% to 23.9%.
  • Transition like Shift Towards Personalized Medicine is expected to add $129.3 million to the Glycerol Phenylbutyrate Liquid market growth by 2030
  • The Glycerol Phenylbutyrate Liquid market is set to add $949 million between 2024 and 2034, with manufacturer targeting Homecare & Speciality Clinics End-User projected to gain a larger market share.
  • With Growth in urea cycle disorders treatment, and Technological advancements in pharmaceutical manufacturing, Glycerol Phenylbutyrate Liquid market to expand 693% between 2024 and 2034.
glycerol phenylbutyrate liquid market size with pie charts of major and emerging country share, CAGR, trends for 2025 and 2032

Opportunities in the Glycerol Phenylbutyrate Liquid

Pharmaceutical companies may collaborate with firms or research institutions to conduct broader clinical trials exploring the effectiveness of glycerol phenylbutyrate liquid, in various potential therapeutic uses.

Growth Opportunities in North America and Europe

North America Outlook

North America is a choice worldwide for glycerol phenylbutyrate liquid due to its advanced healthcare system and the presence of major pharmaceutical companies that cater to the increasing cases of urea cycle disorders in the region has created a lucrative market opportunity, for effective treatments. The recent FDA approval of glycerol phenylbutyrate for treating conditions such as encephalopathy has boosted North America's market position even more significant! Nevertheless this region faces competition from established players like Ultragenyx Pharmaceutical Inc. along with strict regulatory frameworks. Key factors driving growth here involve advancements, in healthcare technology increased awareness of treatments and a healthcare system leaning towards personalized medicine that includes glycerol phenylbutyrate in liquid form.

Europe Outlook

Europe has seen an increase in the use of glycerol phenylbutyrate liquid as it competes with North America fiercely in the market. The surge is mainly due to the rising number of people in the region and the increase in rare diseases along with the advancement of healthcare facilities in Europe. Additionally the region has identified prospects for growth through higher investments in research and development, by both pharmaceutical companies and government agencies.

Market Dynamics and Supply Chain

01

Driver: Growth in Urea Cycle Disorders Treatment, and Increased Funding for Rare Disease Research

Glycerol phenylbutyrate liquid is also mainly utilized for managing cycle disorders and the rise in UCD cases globally plays a crucial role in driving market growth for this treatment option. The noticeable increase in diagnoses can also be attributed to improved knowledge and more advanced diagnostic methods in recent times. Factors that have also contributed to a higher demand for glycerol phenylbutyrate liquid as a remedy. Given the advancements in medical technologies and their utilization trends over time – the utilization of glycerol phenylbutyrate liquid for treating UCD cases shows promising prospects, for further expansion. The market growth of glycerol liquid is also being fueled by enhanced funding and research efforts in the realm of rare diseases, like UCD.
The advancement of pharmaceutical production methods has also led to improvements in the formulation and manufacturing of glycerol phenylbutyrate liquid product quality and potency have also been enhanced due to these developments in the manufacturing processes This progress is also driving market growth as pharmaceutical technology continues to evolve The demand for glycerol phenylbutyrate liquid is also anticipated to increase in line, with these advancements.
02

Restraint: Regulatory Challenges

The market for glycerol liquid is significantly impacted by the complex and strict regulatory guidelines that oversee its manufacturing and usage practices. These rules are in place to guarantee the products safety and effectiveness; ‚ they also tend to impede market progression. For example‚ the lengthy approval procedures lead to delays, in product launches‚ leading to consumer demand and market instability. As a result‚ the financial setback may discourage aspiring businesses from joining this market sector.
03

Opportunity: Breathing Space in Under-Tapped Markets and Customizable Drug Delivery Systems

Glycerol phenylbutyrate liquid is a established medication for treating conditions linked to the urea cycle and shows great promise in growing markets such as India and Brazil where metabolic disorders are often not only adequately addressed due to limited access to advanced medical facilities and specialized medications. Expanding into these markets could lead to growth in sales volume as healthcare spending rises and awareness, about urea cycle disorders increases.
There is a growing interest in the healthcare sector for personalized medicine, rendering a viable for customizing drug delivery systems for glycerol phenylbutyrate liquid. Adapting to patient-specific needs through the creation of personalized formulations or combinational drugs, which integrate glycerol phenylbutyrate liquid with other suitable ingredients, can elevate its efficacy and market reach.
04

Challenge: High Manufacturing Costs

One more obstacle to expanding the market is the costs of manufacturing involved in producing glycerol phenylbutyrate liquid due to intricate chemical procedures and the need for advanced technologies and top notch raw materials. All contributing to increased production expenses that ultimately result in higher product prices, for consumers as a consequence of which consumer uptake may decrease affecting market demand adversely.

Supply Chain Landscape

1
Raw Material Acquisition

Sigma Aldrich

Dow Chemicals

2
Intermediate Manufacturing

CRC Industries

BASF

3
Production

Horizons Pharma

Ikaria

4
End User Industry

Healthcare

Pharmaceutical

Clinical research

*The illustration highlights the key stakeholders within the supply chain ecosystem.

Applications of Glycerol Phenylbutyrate Liquid in Urea Cycle Disorders Treatment, Research & Development & Hepatic Encephalopathy Management

Urea Cycle Disorders Treatment

The use of glycerol liquid is mainly focused on treating Urea Cycle Disorders . This liquid aids in the elimination of nitrogen from the body—a crucial step in managing UCD. Horizon Therapeutics is a player, in this field and is recognized for their product RAVICTI that effectively treats UCD with glycerol phenylbutyrate liquid.

Hepatic Encephalopathy Management

The treatment of encephalopathy also sees positive outcomes with the application of liquid glycerol phenylbutyrate as it helps lower ammonia levels in the bloodstream and eases the burden on the liver while alleviating symptoms linked to hepatic encephalopathy management. Leading pharmaceutical firms, like Bausch Health have strategically established their presence in the market by introducing approaches to manage hepatic encephalopathy effectively.

Research and Development

In the realm of research and development field lately there has been a growing interest in glycerol liquid among scientists looking for new uses in various medical region's due to its important role in controlling metabolic processes. Major companies like Novartis and Pfizer are using glycerol liquid in their extensive research activities to strengthen their position, in the market.

Recent Developments

December 2024

Horizon Therapeutics Pl. launched a version of glycerol phenylbutyrate liquid to meet the needs of a specialized market segment, with high demand.

October 2024

Eli Lilly and Company partnered with Amgen Inc. leading to the creation of a groundbreaking use for glycerol liquid, in metabolic treatments.

August 2024

AstraZeneca Pl c revealed an advancement, in technology aimed at improving the durability and storage lifespan of glycerol phenylbutyrate liquid.

The liquid form of glycerol phenylbutyrate has been a breakthrough in the pharmaceutical industry and offers an innovative way to treat conditions related to nitrogen metabolism issues. Noteworthy advancements, in the market have positively influenced the growth of this product.

Impact of Industry Transitions on the Glycerol Phenylbutyrate Liquid Market

As a core segment of the Pharmaceutical industry, the Glycerol Phenylbutyrate Liquid market develops in line with broader industry shifts. Over recent years, transitions such as Shift Towards Personalized Medicine and Emphasis on Liquid Formulation have redefined priorities across the Pharmaceutical sector, influencing how the Glycerol Phenylbutyrate Liquid market evolves in terms of demand, applications and competitive dynamics. These transitions highlight the structural changes shaping long-term growth opportunities.
01

Shift Towards Personalized Medicine

The field of pharmaceuticals has seen a change moving away from general medications to tailored ones that cater to individual needs with more precise therapies being offered now compared to before. For example glycerol phenylbutyrate liquid, an approved medication by the FDA is specially designed for patients suffering from cycle disorders who cannot be effectively managed solely through dietary protein restriction and amino acid supplementation. This shift towards personalized treatments has led to advancements in drug production methods resulted in changes, within the industry itself and encouraged research and trials aimed at uncovering new personalised treatments. This industry transition is expected to add $129.3 million in the industry revenue between 2024 and 2030.
02

Emphasis on Liquid Formulation

The move from solid to medication is making a big impact on the pharmaceutical field these days for sure! Take the case of glycerol liquid as an example. Its all about easier dosing and administration and tastier too! This kind of shift is a game changer for folks who struggle with swallowing pills easily but need their meds just the same!. Its not only about the patients; this whole shift is also sparking improvements in tech and manufacturing methods across the pharmaceutical scenario and its related industries. Creating new avenues, for patient focused care.

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