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Glycerol Phenylbutyrate Liquid Market
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Glycerol Phenylbutyrate Liquid Market

Author: Debadatta Patel - Senior Consultant, Report ID - DS1802094, Published - March 2025

Segmented in Application (Pharmaceuticals, Nutritional Supplements), End-User (Hospitals, Homecare, Speciality Clinics, Others), Distribution Channel, Product Form, Compound and Regions - Global Industry Analysis, Size, Share, Trends, and Forecast 2024 – 2034

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Global Glycerol Phenylbutyrate Liquid
Market Outlook

The market, for Glycerol phenylbutyrate liquid was estimated at $137.0 million in 2024; and it is anticipated to increase to $474.4 million by 2030 with projections indicating a growth to around $1.3 billion by 2035. This expansion represents a compound annual growth rate (CAGR) of 23.0% over the forecast period. This burgeoning growth can largely be attributed to the increasing global focus on managing the volume of ammonia in the blood, particularly for individuals with urea cycle disorders. Therefore, the significance of glycerol phenylbutyrate liquid is rapidly elevating in the healthcare industry, which remains the products primary market. Key driving factors, such as advancements in healthcare technology, stakeholder investments, and the rising incidence of rare metabolic diseases, are all contributing to its ongoing relevance in pharmaceutical therapies.


Glycerol phenylbutyrate liquid, Therapeutic-grade GPB, is a key player in this dynamic healthcare landscape. The compound serves as a vital nitrogen-binding agent, assisting in the removal of excess nitrogen caused by metabolic processes. This makes GPB instrumental in treating urea cycle disorders, thereby preventing an array of potential complications including nervous system damage and organ failure.


Market Size Forecast & Key Insights

2019
$137M2024
2029
$1.1B2034

Absolute Growth Opportunity = $949M

The Glycerol Phenylbutyrate Liquid market is projected to grow from $137.0 million in 2024 to $1.09 billion in 2034. This represents a CAGR of 23.0%, reflecting rising demand across Urea Cycle Disorders Treatment, Research and Development and Hepatic Encephalopathy Management.

The Glycerol Phenylbutyrate Liquid market is set to add $949 million between 2024 and 2034, with manufacturer targeting Homecare & Speciality Clinics End-User projected to gain a larger market share.

With Growth in urea cycle disorders treatment, and Technological advancements in pharmaceutical manufacturing, Glycerol Phenylbutyrate Liquid market to expand 693% between 2024 and 2034.

Opportunities in the Glycerol Phenylbutyrate Liquid Market

Collaborations for Advanced Research

Pharmaceutical companies may collaborate with firms or research institutions to conduct broader clinical trials exploring the effectiveness of glycerol phenylbutyrate liquid, in various potential therapeutic uses.

Breathing Space in Under-Tapped Markets and Customizable Drug Delivery Systems

Glycerol phenylbutyrate liquid is a established medication for treating conditions linked to the urea cycle and shows great promise in growing markets such as India and Brazil where metabolic disorders are often not only adequately addressed due to limited access to advanced medical facilities and specialized medications. Expanding into these markets could lead to growth in sales volume as healthcare spending rises and awareness, about urea cycle disorders increases.

There is a growing interest in the healthcare sector for personalized medicine, rendering a viable for customizing drug delivery systems for glycerol phenylbutyrate liquid. Adapting to patient-specific needs through the creation of personalized formulations or combinational drugs, which integrate glycerol phenylbutyrate liquid with other suitable ingredients, can elevate its efficacy and market reach.

Growth Opportunities in North America and Europe

Europe Outlook

Europe has seen an increase in the use of glycerol phenylbutyrate liquid as it competes with North America fiercely in the market. The surge is mainly due to the rising number of people in the region and the increase in rare diseases along with the advancement of healthcare facilities in Europe. Additionally the region has identified prospects for growth through higher investments in research and development, by both pharmaceutical companies and government agencies.

North America Outlook

North America is a choice worldwide for glycerol phenylbutyrate liquid due to its advanced healthcare system and the presence of major pharmaceutical companies that cater to the increasing cases of urea cycle disorders in the region has created a lucrative market opportunity, for effective treatments. The recent FDA approval of glycerol phenylbutyrate for treating conditions such as encephalopathy has boosted North America's market position even more significant! Nevertheless this region faces competition from established players like Ultragenyx Pharmaceutical Inc. along with strict regulatory frameworks. Key factors driving growth here involve advancements, in healthcare technology increased awareness of treatments and a healthcare system leaning towards personalized medicine that includes glycerol phenylbutyrate in liquid form.

North America Outlook

North America is a choice worldwide for glycerol phenylbutyrate liquid due to its advanced healthcare system and the presence of major pharmaceutical companies that cater to the increasing cases of urea cycle disorders in the region has created a lucrative market opportunity, for effective treatments. The recent FDA approval of glycerol phenylbutyrate for treating conditions such as encephalopathy has boosted North America's market position even more significant! Nevertheless this region faces competition from established players like Ultragenyx Pharmaceutical Inc. along with strict regulatory frameworks. Key factors driving growth here involve advancements, in healthcare technology increased awareness of treatments and a healthcare system leaning towards personalized medicine that includes glycerol phenylbutyrate in liquid form.

Europe Outlook

Europe has seen an increase in the use of glycerol phenylbutyrate liquid as it competes with North America fiercely in the market. The surge is mainly due to the rising number of people in the region and the increase in rare diseases along with the advancement of healthcare facilities in Europe. Additionally the region has identified prospects for growth through higher investments in research and development, by both pharmaceutical companies and government agencies.

Growth Opportunities in North America and Europe

Established and Emerging Market's Growth Trend 2025–2034

1

Major Markets : United States, Germany, United Kingdom, Japan, China are expected to grow at 22.1% to 32.2% CAGR

2

Emerging Markets : Brazil, South Africa, Malaysia are expected to grow at 17.3% to 23.9% CAGR

Market Analysis Chart

The demand for glycerol liquid in the worldwide market is influenced by various factors. The main factor is the increasing occurrence of cycle disorders for which this liquid variation offers an efficient treatment option. The growing cases of chronic conditions linked to ammonia metabolism have stimulated the need, for glycerol phenylbutyrate liquid serving as a key driver of market expansion.

Recent Developments and Technological Advancement

December 2024

Horizon Therapeutics Pl. launched a version of glycerol phenylbutyrate liquid to meet the needs of a specialized market segment, with high demand.

October 2024

Eli Lilly and Company partnered with Amgen Inc. leading to the creation of a groundbreaking use for glycerol liquid, in metabolic treatments.

August 2024

AstraZeneca Pl c revealed an advancement, in technology aimed at improving the durability and storage lifespan of glycerol phenylbutyrate liquid.

The liquid form of glycerol phenylbutyrate has been a breakthrough in the pharmaceutical industry and offers an innovative way to treat conditions related to nitrogen metabolism issues. Noteworthy advancements, in the market have positively influenced the growth of this product.

Impact of Industry Transitions on the Glycerol Phenylbutyrate Liquid Market

As a core segment of the Pharmaceutical industry, the Glycerol Phenylbutyrate Liquid market develops in line with broader industry shifts. Over recent years, transitions such as Shift Towards Personalized Medicine and Emphasis on Liquid Formulation have redefined priorities across the Pharmaceutical sector, influencing how the Glycerol Phenylbutyrate Liquid market evolves in terms of demand, applications and competitive dynamics. These transitions highlight the structural changes shaping long-term growth opportunities.

1

Shift Towards Personalized Medicine:

The field of pharmaceuticals has seen a change moving away from general medications to tailored ones that cater to individual needs with more precise therapies being offered now compared to before. For example glycerol phenylbutyrate liquid, an approved medication by the FDA is specially designed for patients suffering from cycle disorders who cannot be effectively managed solely through dietary protein restriction and amino acid supplementation. This shift towards personalized treatments has led to advancements in drug production methods resulted in changes, within the industry itself and encouraged research and trials aimed at uncovering new personalised treatments.

2

Emphasis on Liquid Formulation:

The move from solid to medication is making a big impact on the pharmaceutical field these days for sure! Take the case of glycerol liquid as an example. Its all about easier dosing and administration and tastier too! This kind of shift is a game changer for folks who struggle with swallowing pills easily but need their meds just the same!. Its not only about the patients; this whole shift is also sparking improvements in tech and manufacturing methods across the pharmaceutical scenario and its related industries. Creating new avenues, for patient focused care.

Global Events Shaping Future Growth

The chart below highlights how external events including emerging market developments, regulatory changes, and technological disruptions, have added another layer of complexity to the Pharmaceutical industry. These events have disrupted supply networks, changed consumption behavior, and reshaped growth patterns. Together with structural industry transitions, they demonstrate how changes within the Pharmaceutical industry cascade into the Glycerol Phenylbutyrate Liquid market, setting the stage for its future growth trajectory.

Market Dynamics and Supply Chain

Driver: Growth in Urea Cycle Disorders Treatment, and Increased Funding for Rare Disease Research

Glycerol phenylbutyrate liquid is also mainly utilized for managing cycle disorders and the rise in UCD cases globally plays a crucial role in driving market growth for this treatment option. The noticeable increase in diagnoses can also be attributed to improved knowledge and more advanced diagnostic methods in recent times. Factors that have also contributed to a higher demand for glycerol phenylbutyrate liquid as a remedy. Given the advancements in medical technologies and their utilization trends over time – the utilization of glycerol phenylbutyrate liquid for treating UCD cases shows promising prospects, for further expansion.
The market growth of glycerol liquid is also being fueled by enhanced funding and research efforts in the realm of rare diseases, like UCD.
The advancement of pharmaceutical production methods has also led to improvements in the formulation and manufacturing of glycerol phenylbutyrate liquid product quality and potency have also been enhanced due to these developments in the manufacturing processes This progress is also driving market growth as pharmaceutical technology continues to evolve The demand for glycerol phenylbutyrate liquid is also anticipated to increase in line, with these advancements.

Restraint: Regulatory Challenges

The market for glycerol liquid is significantly impacted by the complex and strict regulatory guidelines that oversee its manufacturing and usage practices. These rules are in place to guarantee the products safety and effectiveness; ‚ they also tend to impede market progression. For example‚ the lengthy approval procedures lead to delays, in product launches‚ leading to consumer demand and market instability. As a result‚ the financial setback may discourage aspiring businesses from joining this market sector.

Challenge: High Manufacturing Costs

One more obstacle to expanding the market is the costs of manufacturing involved in producing glycerol phenylbutyrate liquid due to intricate chemical procedures and the need for advanced technologies and top notch raw materials. All contributing to increased production expenses that ultimately result in higher product prices, for consumers as a consequence of which consumer uptake may decrease affecting market demand adversely.

Supply Chain Landscape

Raw Material Acquisition

Sigma Aldrich

Dow Chemicals

Intermediate Manufacturing

CRC Industries

BASF

Production
Horizons Pharma / Ikaria
End User Industry
Healthcare / Pharmaceutical / Clinical research
Raw Material Acquisition

Sigma Aldrich

Dow Chemicals

Intermediate Manufacturing

CRC Industries

BASF

Production

Horizons Pharma

Ikaria

End User Industry

Healthcare

Pharmaceutical

Clinical research

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Leading Providers and Their Strategies

Application AreaIndustryLeading Providers / ConsumersProvider Strategies
Pharmaceutical Manufacturing
Pharmaceuticals
Horizon Therapeutics
Focus on research and development of new therapeutic applications
Plastic Manufacturing
Chemical Industry
Bio-Cat Microbials
Investment in technology to improve the quality of manufactured plastic
Gastronomy and Culinary Arts
Food and Beverage
Sigma-Aldrich Corporation
Emphasis on quality assurance and food-safe production processes
Biofuel Production
Renewable Energy
Vertimass LLC
Adoption of proprietary catalyst technology to maximize biofuel yield

Elevate your strategic vision with in-depth analysis of key applications, leading market players, and their strategies. The report analyzes industry leaders' views and statements on the Glycerol Phenylbutyrate Liquid market's present and future growth.

Our research is created following strict editorial standards. See our Editorial Policy

Applications of Glycerol Phenylbutyrate Liquid in Urea Cycle Disorders Treatment, Research and Development and Hepatic Encephalopathy Management

Urea Cycle Disorders Treatment

The use of glycerol liquid is mainly focused on treating Urea Cycle Disorders . This liquid aids in the elimination of nitrogen from the body—a crucial step in managing UCD. Horizon Therapeutics is a player, in this field and is recognized for their product RAVICTI that effectively treats UCD with glycerol phenylbutyrate liquid.

Research and Development

In the realm of research and development field lately there has been a growing interest in glycerol liquid among scientists looking for new uses in various medical region's due to its important role in controlling metabolic processes. Major companies like Novartis and Pfizer are using glycerol liquid in their extensive research activities to strengthen their position, in the market.

Hepatic Encephalopathy Management

The treatment of encephalopathy also sees positive outcomes with the application of liquid glycerol phenylbutyrate as it helps lower ammonia levels in the bloodstream and eases the burden on the liver while alleviating symptoms linked to hepatic encephalopathy management. Leading pharmaceutical firms, like Bausch Health have strategically established their presence in the market by introducing approaches to manage hepatic encephalopathy effectively.

Glycerol Phenylbutyrate Liquid vs. Substitutes:
Performance and Positioning Analysis

Glycerol phenylbutyrate liquid demonstrates distinctive superiority over its alternatives, providing required therapeutic action with lesser side effects. Its unique market positioning and growth potential lies in its broadening applicability in novel therapeutic areas. These Alternatives specially Sodium Phenylbutyrate Oral Powder has experienced a rapid growth as detailed in our latest report.

Glycerol Phenylbutyrate Liquid
  • Sodium Phenylbutyrate Oral Powder /
  • Buphenyl tablets /
  • Ammonaps granules
    Effective treatment for urea cycle disorders, Improved patient tolerance and absorption
    Expensive, Potential side effects including gastrointestinal distress
    Effective treatment alternatives, broad accessibility
    Limited effectiveness for some patients, potential for adverse reactions

Glycerol Phenylbutyrate Liquid vs. Substitutes:
Performance and Positioning Analysis

Glycerol Phenylbutyrate Liquid

  • Effective treatment for urea cycle disorders, Improved patient tolerance and absorption
  • Expensive, Potential side effects including gastrointestinal distress

Sodium Phenylbutyrate Oral Powder / Buphenyl tablets / Ammonaps granules

  • Effective treatment alternatives, broad accessibility
  • Limited effectiveness for some patients, potential for adverse reactions

Glycerol phenylbutyrate liquid demonstrates distinctive superiority over its alternatives, providing required therapeutic action with lesser side effects. Its unique market positioning and growth potential lies in its broadening applicability in novel therapeutic areas. These Alternatives specially Sodium Phenylbutyrate Oral Powder has experienced a rapid growth as detailed in our latest report.

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Research Methodology

This market research methodology defines the Glycerol Phenylbutyrate Liquid market scope, gathers reliable data, and validates findings using integrated primary and secondary research. Our systematic framework ensures precise market sizing, growth trend analysis, and competitive benchmarking.


Secondary Research Approach


We begin secondary research by defining the targeted market at Country and Regional levels. As part of the Pharmaceutical ecosystem, we analyze Glycerol Phenylbutyrate Liquid across Hospitals, Homecare, and Speciality Clinics Applications. Our team gathers data systematically from country level ministerial sources, industry associations & federations, trade databases, company annual & quarterly reports and other credential sources, enabling us to map global and regional market size, pricing trends, regulatory standards, and technology advancements.


Key Sources Referenced:


We benchmark competitors such as Horizon Therapeutics, Vertice Pharma, and Cipher Pharmaceuticals by reviewing company financial statements, and regulatory filings. Our secondary insights identify key market drivers and constraints, forming the analytical foundation for primary research.


Primary Research Methods


We conduct structured interviews and surveys with industry stakeholders, including Raw Material Acquisition, Intermediate Manufacturing, and Production. Our geographic coverage spans Americas (40%), Europe (30%), Asia-Pacific (25%) and Middle East & Africa (5%). Our online surveys generally achieve a response rate of above 65%, and telephone interviews yield 60%, resulting in above 92% confidence level with a ±7% margin of error.


Through targeted questionnaires and in-depth interviews, we capture purchase intent, adoption barriers, brand perception across Segment Type. We use interview guides to ensure consistency and anonymous survey options to mitigate response bias. These primary insights validate secondary findings and align market sizing with real-world conditions.


Market Engineering & Data Analysis Framework


Our data analysis framework integrates Top-Down, Bottom-Up, and Company Market Share approaches to estimate and project market size with precision.


Top-down & Bottom-Up Process


In Top-down approach, we disaggregate global Pharmaceutical revenues to estimate the Glycerol Phenylbutyrate Liquid segment, using historical growth patterns to set baseline trends. Simultaneously, in Bottom-up approach, we aggregate Country-Level Demand Data to derive regional and global forecasts, which provide granular consumption insights. By reconciling both approaches, we ensure statistical precision and cross-validation accuracy.


We evaluate the supply chain, spanning Raw Material Acquisition (Sigma Aldrich, Dow Chemicals), Intermediate Manufacturing (CRC Industries, BASF), and Production. Our parallel substitute analysis examines Sodium Phenylbutyrate Oral Powder, Buphenyl tablets, and Ammonaps granules, highlighting diversification opportunities and competitive risks.


Company Market Share & Benchmarking


We benchmark leading companies such as Horizon Therapeutics, Vertice Pharma, and Cipher Pharmaceuticals, analyzing their capabilities in pricing, product features, technology adoption, and distribution reach. By assessing company-level revenues and product portfolios, we derive market share comparisons, clarifying competitive positioning and growth trajectories across the ecosystem.


Our integration of data triangulation, supply chain evaluation, and company benchmarking, supported by our proprietary Directional Superposition methodology enables us to deliver precise forecasts and actionable strategic insights into the Glycerol Phenylbutyrate Liquid market.


Quality Assurance and Compliance


We cross-reference secondary data with primary inputs and external expert reviews to confirm consistency. Further, we use stratified sampling, anonymous surveys, third-party interviews, and time-based sampling to reduce bias and strengthen our results.


Our methodology is developed in alignment with ISO 20252 standards and ICC/ESOMAR guidelines for research ethics. The study methodology follows globally recognized frameworks such as ISO 20252 and ICC codes of practice.

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Glycerol Phenylbutyrate Liquid Market Data: Size, Segmentation & Growth Forecast

Report AttributeDetails
Market Value in 2025USD 168 million
Revenue Forecast in 2034USD 1.09 billion
Growth RateCAGR of 23.0% from 2025 to 2034
Base Year for Estimation2024
Industry Revenue 2024137 million
Growth OpportunityUSD 949 million
Historical Data2019 - 2023
Growth Projection / Forecast Period2025 - 2034
Market Size UnitsMarket Revenue in USD million and Industry Statistics
Market Size 2024137 million USD
Market Size 2027254 million USD
Market Size 2029385 million USD
Market Size 2030474 million USD
Market Size 20341.09 billion USD
Market Size 20351.34 billion USD
Report CoverageMarket revenue for past 5 years and forecast for future 10 years, Competitive Analysis & Company Market Share, Strategic Insights & trends
Segments CoveredApplication, End-User, Distribution Channel, Product Form, Compound
Regional scopeNorth America, Europe, Asia Pacific, Latin America and Middle East & Africa
Country scopeU.S., Canada, Mexico, UK, Germany, France, Italy, Spain, China, India, Japan, South Korea, Brazil, Mexico, Argentina, Saudi Arabia, UAE and South Africa
Companies ProfiledHorizon Therapeutics, Vertice Pharma, Cipher Pharmaceuticals, Net Health, Bausch Health, Acerta Pharma, Prospect Pharma, Takeda Pharmaceutical Company, Ardea Biosciences, AstraZeneca, Novartis AG and GlaxoSmithKline plc.
CustomizationFree customization at segment, region or country scope and direct contact with report analyst team for 10 to 20 working hours for any additional niche requirement which is almost equivalent to 10% of report value

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Table of Contents

Industry Insights Report - Table Of Contents

Chapter 1

Executive Summary

Major Markets & Their Performance - Statistical Snapshots

Chapter 2

Research Methodology

2.1Axioms & Postulates
2.2Market Introduction & Research MethodologyEstimation & Forecast Parameters / Major Databases & Sources
Chapter 3

Market Dynamics

3.1Market OverviewDrivers / Restraints / Opportunities / M4 Factors
3.2Market Trends
3.2.1Introduction & Narratives
3.2.2Market Trends - Impact Analysis(Short, Medium & Long Term Impacts)
3.3Supply Chain Analysis
3.4Porter's Five ForcesSuppliers & Buyers' Bargaining Power, Threat of Substitution & New Market Entrants, Competitive Rivalry
Chapter 4

Glycerol Phenylbutyrate Liquid Market Size, Opportunities & Strategic Insights, by Application

4.1Pharmaceuticals
4.2Nutritional Supplements
Chapter 5

Glycerol Phenylbutyrate Liquid Market Size, Opportunities & Strategic Insights, by End-User

5.1Hospitals
5.2Homecare
5.3Speciality Clinics
5.4Others
Chapter 6

Glycerol Phenylbutyrate Liquid Market Size, Opportunities & Strategic Insights, by Distribution Channel

6.1Hospital Pharmacies
6.2Retail Pharmacies
6.3Online Pharmacies
Chapter 7

Glycerol Phenylbutyrate Liquid Market Size, Opportunities & Strategic Insights, by Product Form

7.1Prescription
7.2Over-the-counter
Chapter 8

Glycerol Phenylbutyrate Liquid Market Size, Opportunities & Strategic Insights, by Compound

8.1Pure
8.2Combined Mixtures
Chapter 9

Glycerol Phenylbutyrate Liquid Market, by Region

9.1North America Glycerol Phenylbutyrate Liquid Market Size, Opportunities, Key Trends & Strategic Insights
9.1.1U.S.
9.1.2Canada
9.2Europe Glycerol Phenylbutyrate Liquid Market Size, Opportunities, Key Trends & Strategic Insights
9.2.1Germany
9.2.2France
9.2.3UK
9.2.4Italy
9.2.5The Netherlands
9.2.6Rest of EU
9.3Asia Pacific Glycerol Phenylbutyrate Liquid Market Size, Opportunities, Key Trends & Strategic Insights
9.3.1China
9.3.2Japan
9.3.3South Korea
9.3.4India
9.3.5Australia
9.3.6Thailand
9.3.7Rest of APAC
9.4Middle East & Africa Glycerol Phenylbutyrate Liquid Market Size, Opportunities, Key Trends & Strategic Insights
9.4.1Saudi Arabia
9.4.2United Arab Emirates
9.4.3South Africa
9.4.4Rest of MEA
9.5Latin America Glycerol Phenylbutyrate Liquid Market Size, Opportunities, Key Trends & Strategic Insights
9.5.1Brazil
9.5.2Mexico
9.5.3Rest of LA
9.6CIS Glycerol Phenylbutyrate Liquid Market Size, Opportunities, Key Trends & Strategic Insights
9.6.1Russia
9.6.2Rest of CIS
Chapter 10

Competitive Landscape

10.1Competitive Dashboard & Market Share Analysis
10.2Company Profiles (Overview, Financials, Developments, SWOT)
10.2.1Horizon Therapeutics
10.2.2Vertice Pharma
10.2.3Cipher Pharmaceuticals
10.2.4Net Health
10.2.5Bausch Health
10.2.6Acerta Pharma
10.2.7Prospect Pharma
10.2.8Takeda Pharmaceutical Company
10.2.9Ardea Biosciences
10.2.10AstraZeneca
10.2.11Novartis AG
10.2.12GlaxoSmithKline plc.