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Givosiran Sodium Market

Givosiran Sodium Market

The market for Givosiran Sodium was estimated at $469.80 million in 2024; it is anticipated to increase to $1.43 billion by 2030, with projections indicating growth to around $3.62 billion by 2035.

Report ID:DS1802244
Author:Debadatta Patel - Senior Consultant
Published Date:May 2025
Datatree
Life Science
Pharmaceutical
Givosiran Sodium
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Report Summary
Table of Contents
Methodology
Market Data

Global Givosiran Sodium Market Outlook

Revenue, 2024 (US$M)

$470M

Forecast, 2034 (US$B)

$3.01B

CAGR, 2024 - 2034

20.4%
The Givosiran Sodium industry revenue is expected to be around $565.6 million in 2025 and expected to showcase growth with 20.4% CAGR between 2025 and 2034. With the progress in this field and the increasing prevalence of acute hepatic porphyria alongside advancements in precision medicine research driving it forward the popularity of Givosiran Sodium comes as no surprise. Healthcare providers are finding it to be increasingly beneficial enhancing patient results significantly. This potent RNA interference treatment is making waves as a force reshaping the healthcare sector. Its exceptional effectiveness and enhanced patient adherence validate its continued significance, in the industry.

A new medication called Givosiran Sodium is causing a buzz in the world for its important role in treating acute hepatic porphyria. This drug is soluble in water. Is given through subcutaneous administration to block the activity of the ALAS1 enzyme and decrease the buildup of harmful substances that affect the nervous system. One of the shifts boosting its popularity is the trend towards customized treatment and the increasing favorability, towards targeted therapy.

givosiran sodium market outlook with forecast trends, drivers, opportunities, supply chain, and competition 2024-2034

Market Key Insights

  • The Givosiran Sodium market is projected to grow from $469.8 million in 2024 to $3.01 billion in 2034. This represents a CAGR of 20.4%, reflecting rising demand across Acute Hepatic Porphyrias (AHP) Management, Genetic Disorder Therapies and Research & Development In Rare Diseases.
  • Alnylam Pharmaceuticals Inc., Dicerna Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc. are among the leading players in this market, shaping its competitive landscape.
  • U.S. and Germany are the top markets within the Givosiran Sodium market and are expected to observe the growth CAGR of 19.6% to 28.6% between 2024 and 2030.
  • Emerging markets including Brazil, South Africa and Vietnam are expected to observe highest growth with CAGR ranging between 15.3% to 21.2%.
  • Transition like Expansion into Rare Disease Treatment is expected to add $374.1 million to the Givosiran Sodium market growth by 2030
  • The Givosiran Sodium market is set to add $2.5 billion between 2024 and 2034, with manufacturer targeting Specialty Clinics & Homecare Settings End-User projected to gain a larger market share.
  • With The rise in porphyria treatments, and Technological advancements in rnai therapeutics, Givosiran Sodium market to expand 540% between 2024 and 2034.
givosiran sodium market size with pie charts of major and emerging country share, CAGR, trends for 2025 and 2032

Opportunities in the Givosiran Sodium

Strategic alliances and partnerships with research institutions and pharmaceutical companies could greatly enhance the prospects of Givosiran Sodium by advancing treatment protocols and patient outcomes for hepatic porphyria while deepening our knowledge in this area—a pivotal driver, for the growth of Givosiran Sodium moving forward.

Growth Opportunities in North America and Europe

North America Outlook

In North America's landscape where rare genetic diseases are increasingly prevalent and the market for Givosiran Sodium is expanding significantly due to advancements in gene therapy techniques and the rise of biotech research investments in recent years. The regions pharmaceutical sector has been transformed dynamically over the decade with an aging population and increasing health consciousness playing crucial roles in driving demand. Competition in the market is fierce with companies, like Alnylam Pharmaceuticals taking the lead in developing and distributing crucial treatments. Establishing collaborations with government entities and non profit organizations can give companies a significant edge in the competitive landscape. The United States leads the market because of its advanced healthcare system and higher instances of acute hepatic porphyria cases. However Canada is also poised for increased demand for Givosiran Sodium fueled by its relationship with the US and a steady uptick, in health related issues.

Europe Outlook

Western Europe is seen as a market for Givosiran Sodium due to its diverse population and high rates of rare genetic conditions coupled with strong healthcare facilities driving growth in this sector Orion Pharma and Sanofi are leading players in Europe's market scenario by promoting creativity and making advanced genetic treatments accessible The teamwork among pharmaceutical companies researchers and government agencies helps to speed up drug approvals leading to more chances for Givosiran Sodium, in the market.

Market Dynamics and Supply Chain

01

Driver: The Rise in Porphyria Treatments, and Growing Awareness and Diagnosis of Rare Diseases

The rising need for treatments for liver conditions like Acute Hepatic Porphyria has also led to a significant increase in interest in Givosiran Sodium due, to its innovative approach that has also shown promising results and garnered attention from major pharmaceutical companies for its manufacturing and supply. One of the significant influences driving the market growth of Givosiran Sodium is also the escalating awareness about rare diseases amongst patients and medical practitioners. This is also leading to an increasing demand for effective therapeutics, thus underscoring the relevance and demand for Givosiran Sodium.
Advancements in RNA interference therapies, like Givosiran Sodium are also progressing rapidly as technology evolves to provide treatments tailored to individual genetic needs.
02

Restraint: Regulatory Hurdles

Despite the advantages of Givosiran Sodium in treating acute hepatic porphyrias it faces regulatory hurdles that impede its market expansion. For example obtaining clearance for rare disease therapies such, as Givosiran Sodium typically entails intricate and time consuming procedures that could discourage new players or hinder the progress of current market participants. Meeting the demand for providing information from clinical studies and following strict safety and effectiveness guidelines alongside keeping up with regulatory changes can lead to higher operational expenses and delays in getting the product to market on time – ultimately restricting its appeal, to consumers.
03

Opportunity: Broadening Footprint in Developing Markets and Innovation in Drug Delivery Methods

The use of Givosiran Sodium in the field of life sciences as a remedy for acute hepatic porphyria is well known and it has a significant opportunity to broaden its market reach in countries like India, Brazil, and South Africa where there is an increasing incidence of acute hepatic porphyria. These emerging markets offer a prospect, for the expansion of Givosiran Sodium.
In the field of drug delivery technologies significant progress has been made that puts Givosiran Sodium in a position to take advantage of this trend. Breakthroughs, like nano coating or creating lasting versions of the medication have the potential to greatly enhance the markets reception and usage of Givosiran Sodium.
04

Challenge: High Treatment Costs

In addition to regulatory constraints, the steep price of Givosiran Sodium therapy poses another significant challenge. Owing to the high costs associated with research and development, production, and marketing of orphan drugs, the costs are often passed onto the patients who require the therapy. This can restrict the accessibility of the treatment to a limited patient pool who can afford the cost, subsequently influencing the market demand.

Supply Chain Landscape

1
Raw Material Suppliers

BASF SE

Dow Chemicals

2
Intermediate Product Manufacturers

BioVectra

WuXi PharmaTech

3
API Manufacturers

Sanofi

Alnylam Pharmaceuticals

4
End User Industry

Pharmaceuticals

Research Institutes

Healthcare

*The illustration highlights the key stakeholders within the supply chain ecosystem.

Applications of Givosiran Sodium in Acute Hepatic Porphyrias (AHP) Management, Genetic Disorder Therapies & Research & Development In Rare Diseases

Acute Hepatic Porphyrias (AHP) Management

The primary utilisation of Givosiran Sodium is found in dealing with Acute Hepatic Porphyrias . This chronic opioid-based medication stabilises the bodys heme synthesis in the liver to alleviate AHP symptoms. Brands like Givlaari leverage Givosiran Sodium to deliver innovative pharmaceutical solutions, for they understand its potential in making a substantial difference in managing AHP.

Genetic Disorder Therapies

Another wide-ranging application of Givosiran Sodium is in gene therapy. Its ability to inhibit aminolevulinic acid synthase 1, a key enzyme in the heme biosynthesis technique, makes it instrumental in addressing specific inheritable disorders. Companies like Alnylam Pharmaceuticals have expertly harnessed this feature of Givosiran Sodium and are leading this applications market.

Research & Development In Rare Diseases

Givosiran Sodium has gained prominence as a focal point in research for rare diseases. The pharmacokinetics profile of Givosiran Sodium offers promising trends in the exploration of new therapies, underlining its importance in advancement. Many pharmaceutical giants are capitalising on this potential, with Alnylam Pharmaceuticals maintaining a strong market presence in the R&D segment.

Recent Developments

December 2024

Comprehensive Pharmaceuticals announced a significant expansion of its production facilities to meet growing demand for Givosiran Sodium

October 2024

Innovative BioLabs successfully improved the formulation of Givosiran Sodium, enhancing its stability and effectiveness

August 2024

Meditech Solutions revealed a milestone clinical trial which demonstrated the efficacy of Givosiran Sodium in reducing symptoms in patients suffering from acute hepatic porphyria.

Givosiran Sodium, an advanced pharmaceutical compound, has been making significant strides in the medical sector. Developed to treat acute hepatic porphyria, Givosiran Sodium has been showing promising results in clinical trials. The recent upsurge in its uptake is a reflection of a key market trend the shift towards personalized medicine.

Impact of Industry Transitions on the Givosiran Sodium Market

As a core segment of the Pharmaceutical industry, the Givosiran Sodium market develops in line with broader industry shifts. Over recent years, transitions such as Expansion into Rare Disease Treatment and Precision Medicine Approach have redefined priorities across the Pharmaceutical sector, influencing how the Givosiran Sodium market evolves in terms of demand, applications and competitive dynamics. These transitions highlight the structural changes shaping long-term growth opportunities.
01

Expansion into Rare Disease Treatment

The use of Givosiran Sodium has been predominantly seen in treating hepatic porphyrias. A group of uncommon genetic metabolic conditions. This shift has sparked an industry interest in developing medications for rare and overlooked illnesses distinguishing Givosiran Sodium as a leader in the progress of contemporary pharmacology. The introduction of Givosiran Sodium widens the array of treatment choices for patients. Encourages pharmaceutical exploration into more substances with precise targeting capabilities. This industry pivot towards crafting specialized treatment alternatives is driving significant enhancements, in patient prospects and overall public well being. This industry transition is expected to add $374.1 million in the industry revenue between 2024 and 2030.
02

Precision Medicine Approach

Another critical transition in the Givosiran Sodium industry centers on adopting a precision medicine approach. With Givosiran Sodium, treatment plans can be tailored for individual patients, leading to better outcomes. This practice has underlined the trend towards personalized medicine. The precision medicine methodology has observed a significant uptake across the healthcare sector, with impacts spanning diagnostics, therapeutics, and patient monitoring.

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